Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 829185..829702 Replicon chromosome
Accession NZ_CP041725
Organism Staphylococcus lugdunensis strain SL117

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag FO457_RS03935 Protein ID WP_002461192.1
Coordinates 829352..829702 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag FO457_RS03930 Protein ID WP_002461193.1
Coordinates 829185..829355 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO457_RS03905 825010..825492 + 483 WP_002478975.1 PH domain-containing protein -
FO457_RS03910 825485..826999 + 1515 WP_002461198.1 PH domain-containing protein -
FO457_RS03915 826986..827498 + 513 WP_002478976.1 PH domain-containing protein -
FO457_RS03920 827510..827902 + 393 WP_002461196.1 holo-ACP synthase -
FO457_RS03925 827950..829098 + 1149 WP_002478977.1 alanine racemase -
FO457_RS03930 829185..829355 + 171 WP_002461193.1 hypothetical protein Antitoxin
FO457_RS03935 829352..829702 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FO457_RS03940 830136..831137 + 1002 WP_002478978.1 PP2C family protein-serine/threonine phosphatase -
FO457_RS03945 831228..831554 + 327 WP_002461190.1 anti-sigma factor antagonist -
FO457_RS03950 831556..832035 + 480 WP_002478979.1 anti-sigma B factor RsbW -
FO457_RS03955 832010..832780 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T129041 WP_002461192.1 NZ_CP041725:829352-829702 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T129041 NZ_CP041725:829352-829702 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGCTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT129041 WP_002461193.1 NZ_CP041725:829185-829355 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT129041 NZ_CP041725:829185-829355 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTCCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References