Detailed information of TA system TA129039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1304323..1305132
• Replicon: chromosome
• Accession: NZ_CP041724
• Organism: Staphylococcus lugdunensis strain SL55

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: FO456_RS06190
• Protein ID: WP_002458758.1
• Coordinates: 1304962..1305132 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: FO456_RS06185
• Protein ID: WP_070648686.1
• Coordinates: 1304323..1304922 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO456_RS06165	1299910..1301367	+	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-
FO456_RS06170	1301360..1302085	+	726	WP_070648683.1	amino acid ABC transporter ATP-binding protein	-
FO456_RS06175	1302543..1303685	+	1143	WP_103284502.1	tRNA epoxyqueuosine(34) reductase QueG	-
FO456_RS06180	1303687..1304157	+	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FO456_RS06185	1304323..1304922	+	600	WP_070648686.1	glucosamine-6-phosphate isomerase	Antitoxin
FO456_RS06190	1304962..1305132	+	171	WP_002458758.1	hypothetical protein	Toxin
FO456_RS06195	1305306..1305701	+	396	WP_002458759.1	hypothetical protein	-
FO456_RS06200	1305829..1307214	+	1386	WP_070648688.1	class II fumarate hydratase	-
FO456_RS06205	1307279..1308115	-	837	WP_002477978.1	RluA family pseudouridine synthase	-
FO456_RS06210	1308283..1309395	+	1113	WP_060795476.1	GAF domain-containing sensor histidine kinase	-
FO456_RS06215	1309417..1310040	+	624	WP_002477980.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T129039 WP_002458758.1 NZ_CP041724:1304962-1305132 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T129039 NZ_CP041724:1304962-1305132 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22637.55 Da
• Isoelectric Point: 4.9539

>AT129039 WP_070648686.1 NZ_CP041724:1304323-1304922 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLMLQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT129039 NZ_CP041724:1304323-1304922 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATGTTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA