Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1164603..1165120 Replicon chromosome
Accession NZ_CP041724
Organism Staphylococcus lugdunensis strain SL55

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag FO456_RS05405 Protein ID WP_002461192.1
Coordinates 1164770..1165120 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag FO456_RS05400 Protein ID WP_002461193.1
Coordinates 1164603..1164773 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO456_RS05375 1160428..1160910 + 483 WP_002492078.1 PH domain-containing protein -
FO456_RS05380 1160903..1162417 + 1515 WP_070647976.1 PH domain-containing protein -
FO456_RS05385 1162404..1162916 + 513 WP_002478976.1 PH domain-containing protein -
FO456_RS05390 1162928..1163320 + 393 WP_002461196.1 holo-ACP synthase -
FO456_RS05395 1163368..1164516 + 1149 WP_070647975.1 alanine racemase -
FO456_RS05400 1164603..1164773 + 171 WP_002461193.1 hypothetical protein Antitoxin
FO456_RS05405 1164770..1165120 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FO456_RS05410 1165554..1166555 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
FO456_RS05415 1166646..1166972 + 327 WP_070647974.1 anti-sigma factor antagonist -
FO456_RS05420 1166974..1167453 + 480 WP_012990787.1 anti-sigma B factor RsbW -
FO456_RS05425 1167428..1168198 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T129038 WP_002461192.1 NZ_CP041724:1164770-1165120 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T129038 NZ_CP041724:1164770-1165120 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT129038 WP_002461193.1 NZ_CP041724:1164603-1164773 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT129038 NZ_CP041724:1164603-1164773 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References