Detailed information of TA system TA129034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 119762..120280
• Replicon: chromosome
• Accession: NZ_CP041723
• Organism: Staphylococcus lugdunensis strain SL29

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: FO455_RS00635
• Protein ID: WP_002478973.1
• Coordinates: 120068..120280 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A853V130
• Locus tag: FO455_RS00630
• Protein ID: WP_002492098.1
• Coordinates: 119762..120055 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO455_RS00610	115362..116000	+	639	WP_002478970.1	thiamine phosphate synthase	-
FO455_RS00615	116090..116965	+	876	WP_002461212.1	membrane protein insertase YidC	-
FO455_RS00620	117349..117990	-	642	WP_002478971.1	HD domain-containing protein	-
FO455_RS00625	118112..119596	-	1485	WP_002478972.1	cardiolipin synthase	-
FO455_RS00630	119762..120055	+	294	WP_002492098.1	copper-sensing transcriptional repressor CsoR	Antitoxin
FO455_RS00635	120068..120280	+	213	WP_002478973.1	heavy-metal-associated domain-containing protein	Toxin
FO455_RS00640	120371..120508	+	138	WP_002461206.1	hypothetical protein	-
FO455_RS00645	120922..122112	-	1191	WP_002461205.1	rod shape-determining protein RodA	-
FO455_RS00650	122468..123538	+	1071	WP_002461204.1	D-alanine--D-alanine ligase	-
FO455_RS00655	123556..124914	+	1359	WP_002478974.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-90)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8070.03 Da
• Isoelectric Point: 3.9947

>T129034 WP_002478973.1 NZ_CP041723:120068-120280 [Staphylococcus lugdunensis]
VEKRLIYITNVTSEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDAGYHAIDDL

Nucleotide

• Length: 213 bp

>T129034 NZ_CP041723:120068-120280 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11177.85 Da
• Isoelectric Point: 6.6367

>AT129034 WP_002492098.1 NZ_CP041723:119762-120055 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Nucleotide

• Length: 294 bp

>AT129034 NZ_CP041723:119762-120055 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAAATGCTAAAAGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V130