Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1101319..1102115 Replicon chromosome
Accession NZ_CP041722
Organism Staphylococcus lugdunensis strain SL13

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FO454_RS05025 Protein ID WP_070866272.1
Coordinates 1101319..1101780 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FO454_RS05030 Protein ID WP_070817183.1
Coordinates 1101792..1102115 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO454_RS05000 1097072..1097413 + 342 WP_002479428.1 DUF1450 domain-containing protein -
FO454_RS05005 1097754..1098944 - 1191 Protein_958 FAD-dependent oxidoreductase -
FO454_RS05010 1098973..1100355 - 1383 WP_085317587.1 recombinase family protein -
FO454_RS05015 1100421..1100621 - 201 WP_070866295.1 hypothetical protein -
FO454_RS05020 1100779..1101300 - 522 WP_070866271.1 hypothetical protein -
FO454_RS05025 1101319..1101780 - 462 WP_070866272.1 ImmA/IrrE family metallo-endopeptidase Toxin
FO454_RS05030 1101792..1102115 - 324 WP_070817183.1 helix-turn-helix domain-containing protein Antitoxin
FO454_RS05035 1102280..1102528 + 249 WP_070817182.1 helix-turn-helix domain-containing protein -
FO454_RS13130 1102544..1102714 + 171 WP_176746548.1 hypothetical protein -
FO454_RS05040 1102703..1102912 - 210 WP_000033736.1 hypothetical protein -
FO454_RS05045 1102959..1103831 + 873 WP_070866296.1 ParB N-terminal domain-containing protein -
FO454_RS05050 1103824..1104591 + 768 WP_070866273.1 ParB N-terminal domain-containing protein -
FO454_RS05055 1105013..1105210 + 198 WP_070866274.1 helix-turn-helix transcriptional regulator -
FO454_RS05060 1105224..1105535 + 312 WP_070866275.1 hypothetical protein -
FO454_RS05065 1105483..1105866 - 384 WP_002478859.1 hypothetical protein -
FO454_RS05070 1106094..1106273 + 180 WP_070866276.1 hypothetical protein -
FO454_RS05075 1106342..1106827 + 486 WP_002478865.1 siphovirus Gp157 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1098973..1135937 36964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(19-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18195.72 Da        Isoelectric Point: 5.2774

>T129030 WP_070866272.1 NZ_CP041722:c1101780-1101319 [Staphylococcus lugdunensis]
MGLYEEMLIKHDYIEIKETDVMPDNLSGVWLDDLILINSNLPETRKTEVLYEELAHHKLTYGNILDQSKWINRKFENYAR
RHGYEAALPLRIIVEAHNYGVSSLYELADYVQLSEEYIAEILKHYKNKYGIGTHYGEYLITFDQLRVFKYKEI

Download         Length: 462 bp

>T129030 NZ_CP041722:c1101780-1101319 [Staphylococcus lugdunensis]
ATGGGATTGTACGAAGAGATGTTAATAAAACATGATTACATAGAAATTAAAGAAACAGATGTTATGCCCGATAATTTATC
GGGTGTGTGGTTAGATGACTTAATTTTAATCAATAGTAATCTACCTGAAACACGAAAAACCGAAGTCTTATACGAAGAAT
TAGCACATCATAAACTTACATATGGGAATATCTTAGACCAGTCTAAATGGATTAACCGTAAATTTGAAAACTACGCAAGA
CGTCATGGATATGAAGCTGCATTGCCCTTGCGTATTATTGTGGAGGCACATAACTATGGTGTAAGTAGCTTATATGAACT
AGCTGATTATGTTCAATTAAGTGAAGAGTACATAGCAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGAACTC
ACTACGGAGAATACTTAATTACATTTGATCAGTTGAGGGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12266.97 Da        Isoelectric Point: 9.7735

>AT129030 WP_070817183.1 NZ_CP041722:c1102115-1101792 [Staphylococcus lugdunensis]
MRTSAEIGKLIKQLRKKNNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALNVTPESLLLKNKQPETEVQHRA
AHLEGELTDDEWQRVLDYADYIKSKRK

Download         Length: 324 bp

>AT129030 NZ_CP041722:c1102115-1101792 [Staphylococcus lugdunensis]
ATGAGAACTTCAGCAGAAATAGGTAAGTTAATAAAACAACTACGTAAAAAGAACAATGTAAATTTAACTGATTTTGCAAC
TAAAATAGGTGTTAATAAATCTACTTTGTCAAGATATGAAAATGGTAGTAGAAAAATACCTATGGAAGATATAGCTGAAA
TCGCAAATGCATTGAATGTTACCCCAGAAAGTTTATTATTAAAAAATAAACAACCAGAAACCGAAGTACAACATCGTGCA
GCTCATCTTGAAGGCGAACTAACAGATGATGAATGGCAACGTGTATTAGACTACGCAGATTATATTAAAAGTAAGCGAAA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References