Detailed information of TA system TA129027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2562033..2563075
• Replicon: chromosome
• Accession: NZ_CP041713
• Organism: Legionella geestiana strain HL-0438-4026

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0W0U467
• Locus tag: E3226_RS11745
• Protein ID: WP_028387170.1
• Coordinates: 2562033..2562767 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: E3226_RS11750
• Protein ID: WP_081776818.1
• Coordinates: 2562764..2563075 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3226_RS11730	2557596..2560559	+	2964	WP_135842872.1	mechanosensitive ion channel	-
E3226_RS11735	2560516..2561196	+	681	WP_028387168.1	DNA mismatch repair endonuclease MutH	-
E3226_RS11740	2561547..2561939	-	393	WP_115152876.1	hypothetical protein	-
E3226_RS11745	2562033..2562767	-	735	WP_028387170.1	RES family NAD+ phosphorylase	Toxin
E3226_RS11750	2562764..2563075	-	312	WP_081776818.1	DUF2384 domain-containing protein	Antitoxin
E3226_RS11755	2563282..2565330	-	2049	WP_135842873.1	hypothetical protein	-
E3226_RS11760	2565841..2566620	-	780	WP_135842874.1	SDR family NAD(P)-dependent oxidoreductase	-
E3226_RS11765	2566607..2567881	-	1275	WP_135842875.1	HAAAP family serine/threonine permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (59-194)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (53-101)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 27775.13 Da
• Isoelectric Point: 5.3524

>T129027 WP_028387170.1 NZ_CP041713:c2562767-2562033 [Legionella geestiana]
VNLWQQLQGEAHIRPLSADPWRVVEAQHLSTTRFLVDSMEEHDLLEAMIESSKPAIEPSSDYLIYTPFRYPPLDYGSRFG
SAFEPSLWYGSLALKTAFAEVSWYRRLFLAQTSAELGYVETLLTAFQTRLETESGIHLSEPPFHEHREVISAPHTYATSQ
TLGSAMREAGVEVFSYYSARSEEPAINIAAFTSQVFRRKNGQFIRNQQTWQCIASKDTAEITRISLDGKQRYRFEGAVSF
ELGC

Nucleotide

• Length: 735 bp

>T129027 NZ_CP041713:c2562767-2562033 [Legionella geestiana]
GTGAACCTCTGGCAGCAGCTTCAGGGAGAAGCGCACATCCGCCCCTTGAGCGCAGACCCCTGGCGTGTGGTGGAAGCCCA
GCACCTTTCCACAACACGATTTCTCGTGGACAGCATGGAAGAGCATGACCTCCTTGAAGCCATGATTGAGTCCTCAAAAC
CCGCCATTGAGCCCAGCTCCGACTACCTTATTTACACGCCCTTTCGCTACCCGCCTCTAGATTATGGCTCGCGGTTTGGG
AGTGCATTTGAGCCCTCACTCTGGTATGGCTCACTTGCGCTTAAAACCGCTTTTGCCGAAGTGAGCTGGTACCGCCGACT
CTTTCTGGCACAAACCAGTGCTGAACTTGGCTATGTTGAAACGCTTCTCACTGCGTTTCAAACGCGCCTTGAAACAGAAA
GTGGCATTCATCTTTCAGAACCGCCCTTTCACGAACATCGCGAAGTAATTTCAGCGCCCCATACCTACGCAACCAGCCAG
ACACTGGGAAGCGCCATGCGCGAAGCTGGTGTTGAAGTCTTCAGCTATTATTCGGCACGCTCAGAAGAGCCCGCCATTAA
TATTGCCGCATTCACATCGCAGGTTTTTCGCAGAAAGAACGGTCAATTTATCAGAAACCAACAAACCTGGCAGTGCATTG
CCAGCAAAGATACGGCGGAAATCACCCGCATCAGCCTTGATGGAAAACAACGCTACCGTTTTGAGGGTGCAGTGTCTTTT
GAACTGGGGTGTTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11633.44 Da
• Isoelectric Point: 9.8579

>AT129027 WP_081776818.1 NZ_CP041713:c2563075-2562764 [Legionella geestiana]
MCTHYNLSARELSEILGVSEASTTRMHQGKKWISPDSKEGEIALLLLRVYRSLNALVGNHNEKAQSWLRAQNHYLRCTPV
NALKTVTGLVEVVRYLDALRGKL

Nucleotide

• Length: 312 bp

>AT129027 NZ_CP041713:c2563075-2562764 [Legionella geestiana]
ATGTGTACCCATTATAACCTGAGTGCGCGTGAGCTTTCGGAAATCCTTGGGGTCAGTGAGGCCAGTACCACCCGCATGCA
CCAGGGGAAAAAATGGATTAGCCCGGATTCTAAAGAAGGTGAAATTGCCCTGCTGCTCCTGCGGGTGTATCGAAGCCTCA
ATGCGCTTGTTGGTAATCACAATGAAAAAGCACAAAGCTGGCTGCGTGCGCAAAACCATTACCTGCGCTGCACACCGGTT
AATGCCTTAAAAACTGTGACGGGGCTTGTGGAGGTGGTGCGCTACCTCGATGCTCTGCGGGGGAAACTGTGA

Structures

Toxin

• AlphaFold DB: A0A0W0U467