Detailed information of TA system TA129025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 872522..873092
• Replicon: chromosome
• Accession: NZ_CP041713
• Organism: Legionella geestiana strain HL-0438-4026

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0W0TP77
• Locus tag: E3226_RS04145
• Protein ID: WP_028387426.1
• Coordinates: 872808..873092 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E3226_RS04140
• Protein ID: WP_081776830.1
• Coordinates: 872522..872815 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3226_RS04120	868534..870855	+	2322	WP_162150901.1	ankyrin repeat domain-containing protein	-
E3226_RS04125	870899..871153	-	255	WP_058387133.1	hypothetical protein	-
E3226_RS04130	871215..871397	+	183	Protein_762	Tn3 family transposase	-
E3226_RS04135	871563..872242	+	680	Protein_763	Tn3 family transposase	-
E3226_RS04140	872522..872815	+	294	WP_081776830.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E3226_RS04145	872808..873092	+	285	WP_028387426.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
E3226_RS04150	873267..874136	-	870	WP_028387425.1	hypothetical protein	-
E3226_RS04155	874322..875452	-	1131	WP_115152856.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	871712..872242	530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-57)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10702.22 Da
• Isoelectric Point: 4.4843

>T129025 WP_028387426.1 NZ_CP041713:872808-873092 [Legionella geestiana]
VPELEWLALARADLLEIVDYISDDNPDAAQRVKDDIEAKVAKLPDFPKIGRPGRIEGTRELVVWANYIIVYQEDAFAIQI
LRVLHAAQQWPPSH

Nucleotide

• Length: 285 bp

>T129025 NZ_CP041713:872808-873092 [Legionella geestiana]
GTGCCTGAATTGGAATGGTTAGCTTTAGCTCGTGCCGATCTTTTAGAGATTGTAGACTATATCTCAGATGACAACCCAGA
TGCAGCCCAGCGCGTAAAGGATGATATTGAGGCGAAAGTCGCAAAACTACCAGATTTTCCTAAAATTGGCCGTCCTGGTC
GAATAGAAGGAACCAGAGAATTGGTCGTCTGGGCGAATTATATTATCGTGTATCAAGAAGATGCTTTTGCCATTCAAATA
CTTCGTGTGTTGCATGCGGCACAACAGTGGCCACCATCCCATTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10773.40 Da
• Isoelectric Point: 10.5548

>AT129025 WP_081776830.1 NZ_CP041713:872522-872815 [Legionella geestiana]
MAHTSMLHVRVDDKLKADAAKNLASFGLTVSDAVRILLTRITKEGGLPVGLTADPEAHDAWFRNKVKEALADTRPTVSHK
QVMDEAQTLIDRKRRRA

Nucleotide

• Length: 294 bp

>AT129025 NZ_CP041713:872522-872815 [Legionella geestiana]
ATGGCTCATACTTCAATGCTGCATGTTCGCGTAGACGATAAGTTGAAGGCTGATGCAGCGAAAAATCTTGCAAGTTTTGG
TTTGACTGTATCTGATGCCGTCCGTATTTTATTGACTCGCATAACCAAAGAAGGCGGCTTGCCCGTTGGATTAACGGCTG
ATCCAGAAGCACATGATGCTTGGTTCCGTAACAAGGTGAAAGAAGCTCTCGCTGACACGCGACCCACTGTATCTCATAAA
CAGGTAATGGACGAGGCACAAACATTAATTGATCGGAAGCGTCGCCGTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0W0TP77