Detailed information of TA system TA129024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1271039..1271634
• Replicon: chromosome
• Accession: NZ_CP041698
• Organism: Chlorobium phaeovibrioides strain PhvTcv-s14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5M8ID56
• Locus tag: FNV82_RS06125
• Protein ID: WP_011889905.1
• Coordinates: 1271039..1271344 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5M8I9X4
• Locus tag: FNV82_RS06130
• Protein ID: WP_011889904.1
• Coordinates: 1271341..1271634 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNV82_RS06095	1266431..1266742	-	312	WP_149997960.1	hypothetical protein	-
FNV82_RS06100	1266987..1267448	+	462	WP_149997805.1	hypothetical protein	-
FNV82_RS06105	1267420..1268358	+	939	WP_149997806.1	DDE-type integrase/transposase/recombinase	-
FNV82_RS06110	1268334..1268615	-	282	WP_149997961.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
FNV82_RS06115	1268749..1269039	+	291	WP_011889907.1	transposase	-
FNV82_RS06120	1269090..1270598	+	1509	WP_149997962.1	Fic family protein	-
FNV82_RS06125	1271039..1271344	+	306	WP_011889905.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FNV82_RS06130	1271341..1271634	+	294	WP_011889904.1	putative addiction module antidote protein	Antitoxin
FNV82_RS06135	1271635..1271829	+	195	WP_126343173.1	hypothetical protein	-
FNV82_RS06140	1272157..1272363	+	207	WP_149997963.1	helix-turn-helix transcriptional regulator	-
FNV82_RS06145	1272367..1272690	+	324	WP_011889902.1	HipA N-terminal domain-containing protein	-
FNV82_RS06150	1272694..1273650	+	957	WP_149997964.1	HipA domain-containing protein	-
FNV82_RS06155	1274145..1274525	+	381	WP_011889900.1	MbcA/ParS/Xre antitoxin family protein	-
FNV82_RS06160	1274557..1275189	+	633	WP_149997965.1	RES family NAD+ phosphorylase	-
FNV82_RS06165	1275294..1275719	-	426	WP_191326245.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (6-97)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11513.23 Da
• Isoelectric Point: 9.8054

>T129024 WP_011889905.1 NZ_CP041698:1271039-1271344 [Chlorobium phaeovibrioides]
MNTFIRSSNFDAWLSALKDQKAKARILCRIQSAMHGNFGDCEPVGEGISEMRIHMGPGYRLYYTRTEKTVYFLLAGGNKR
TQGKDIVRAKELARELKETEP

Nucleotide

• Length: 306 bp

>T129024 NZ_CP041698:1271039-1271344 [Chlorobium phaeovibrioides]
ATGAACACCTTCATCCGATCATCCAATTTCGATGCCTGGCTCAGTGCCCTGAAAGACCAGAAAGCGAAAGCAAGGATTCT
CTGCCGCATTCAGAGCGCCATGCACGGAAACTTTGGCGATTGTGAACCGGTAGGTGAAGGAATATCAGAAATGCGGATTC
ATATGGGGCCAGGATACCGGCTCTATTACACGCGAACAGAAAAAACGGTCTATTTCCTGCTTGCTGGCGGCAACAAGCGA
ACACAGGGAAAAGACATTGTCCGTGCTAAGGAATTAGCCCGAGAACTCAAGGAAACAGAACCATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10298.75 Da
• Isoelectric Point: 5.8148

>AT129024 WP_011889904.1 NZ_CP041698:1271341-1271634 [Chlorobium phaeovibrioides]
MKTTYTTFEIAEYLDNDEVIAEYLSLAAADKNPDVFIAALGDVAKAKGMASIAKTAGLGRESLYKALKTGARPRFETINA
VLHAIGAKFTVTSADPS

Nucleotide

• Length: 294 bp

>AT129024 NZ_CP041698:1271341-1271634 [Chlorobium phaeovibrioides]
ATGAAAACAACCTACACGACATTTGAAATTGCCGAATACCTCGATAACGATGAGGTCATTGCAGAATACCTTTCTCTTGC
GGCTGCAGACAAAAACCCCGATGTGTTCATTGCCGCTCTCGGCGATGTCGCCAAAGCAAAAGGAATGGCCAGCATAGCCA
AAACTGCCGGTCTCGGTCGTGAAAGCCTGTATAAAGCGCTGAAAACTGGTGCCCGGCCGCGCTTTGAAACCATCAATGCC
GTCCTGCATGCCATTGGAGCAAAATTCACGGTAACGAGTGCCGATCCTTCTTGA

Structures

Toxin

• AlphaFold DB: A0A5M8ID56

Antitoxin

• AlphaFold DB: A0A5M8I9X4