Detailed information of TA system TA129019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3994643..3995292
• Replicon: chromosome
• Accession: NZ_CP041694
• Organism: Cellulosimicrobium cellulans strain NEB113

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOG94_RS17755
• Protein ID: WP_137281522.1
• Coordinates: 3994870..3995292 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOG94_RS17750
• Protein ID: WP_170982206.1
• Coordinates: 3994643..3994873 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOG94_RS17735	3991763..3992317	-	555	WP_021479810.1	hypoxanthine phosphoribosyltransferase	-
FOG94_RS17740	3992323..3993423	-	1101	WP_137281519.1	tRNA lysidine(34) synthetase TilS	-
FOG94_RS17745	3993427..3994641	-	1215	WP_137281520.1	zinc-dependent metalloprotease	-
FOG94_RS17750	3994643..3994873	+	231	WP_170982206.1	antitoxin	Antitoxin
FOG94_RS17755	3994870..3995292	+	423	WP_137281522.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOG94_RS17760	3995327..3996739	-	1413	WP_137281523.1	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	-
FOG94_RS17765	3996999..3997502	+	504	WP_034655165.1	inorganic diphosphatase	-
FOG94_RS17770	3997574..3998959	-	1386	WP_137281524.1	C40 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15058.14 Da
• Isoelectric Point: 5.6065

>T129019 WP_137281522.1 NZ_CP041694:3994870-3995292 [Cellulosimicrobium cellulans]
VSTLYLLDTNVLVALLRGHGAAARPRLREAEGRVAVSTVSEMELEYGVERSQDPPRNRQAVDELLSLVDVLPFDSLAAMH
AGRVRAVLAARGTPVGPYDALLAGHARSLGLVLVTNNVREFSRVPGLEVEDWLADATHGP

Nucleotide

• Length: 423 bp

>T129019 NZ_CP041694:3994870-3995292 [Cellulosimicrobium cellulans]
GTGAGCACCCTCTACCTGCTCGACACGAACGTGCTCGTCGCCCTCCTCCGCGGGCACGGCGCAGCCGCGCGTCCGAGGCT
GCGCGAGGCGGAGGGGCGCGTCGCCGTCTCGACCGTGAGCGAGATGGAGCTCGAGTACGGCGTGGAGCGGTCGCAGGACC
CGCCCCGCAACCGGCAGGCGGTCGACGAGCTGCTGTCGCTCGTCGACGTGCTGCCCTTCGACAGCCTGGCGGCGATGCAC
GCCGGCAGGGTCCGCGCAGTCCTCGCGGCCCGCGGCACCCCTGTCGGCCCGTACGACGCGCTCCTCGCCGGGCACGCCCG
GTCGCTCGGGCTCGTGCTGGTGACCAACAACGTCCGCGAGTTCTCCCGCGTGCCCGGCCTCGAGGTCGAGGACTGGCTGG
CGGACGCGACGCACGGCCCCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8375.33 Da
• Isoelectric Point: 5.8065

>AT129019 WP_170982206.1 NZ_CP041694:3994643-3994873 [Cellulosimicrobium cellulans]
VRTTVFRSNTTQAVRLPKAVALPDDVREVDVRAVGRSRVITPAGSGWDEWFEHGLRVGPGFLADRDQGTADEREAL

Nucleotide

• Length: 231 bp

>AT129019 NZ_CP041694:3994643-3994873 [Cellulosimicrobium cellulans]
GTGCGCACGACGGTGTTCCGCAGCAACACGACGCAGGCGGTCCGGCTGCCCAAGGCGGTCGCGCTGCCCGACGACGTCCG
GGAGGTGGACGTCCGGGCCGTCGGCCGGTCACGGGTCATCACCCCGGCCGGCTCCGGGTGGGACGAGTGGTTCGAGCACG
GCCTGCGCGTCGGTCCCGGCTTCCTCGCCGACCGCGACCAGGGCACCGCGGACGAGCGCGAGGCCCTGTGA