Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-YefM
Location 390242..390789 Replicon chromosome
Accession NZ_CP041694
Organism Cellulosimicrobium cellulans strain NEB113

Toxin (Protein)


Gene name relE Uniprot ID A0A1G7ISR9
Locus tag FOG94_RS01680 Protein ID WP_074803800.1
Coordinates 390511..390789 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A085LF15
Locus tag FOG94_RS01675 Protein ID WP_034653834.1
Coordinates 390242..390514 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOG94_RS01645 385283..385885 + 603 WP_137281291.1 TetR family transcriptional regulator -
FOG94_RS01650 385845..386426 - 582 WP_137281292.1 GNAT family N-acetyltransferase -
FOG94_RS01655 386596..388893 + 2298 WP_137281293.1 carbon starvation protein A -
FOG94_RS18815 388896..389156 + 261 WP_163185575.1 YbdD/YjiX family protein -
FOG94_RS01665 389175..389636 + 462 WP_137281294.1 hypothetical protein -
FOG94_RS01670 389642..390160 + 519 WP_137281295.1 hypothetical protein -
FOG94_RS01675 390242..390514 + 273 WP_034653834.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOG94_RS01680 390511..390789 + 279 WP_074803800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOG94_RS01685 390812..391291 - 480 WP_137281296.1 META domain-containing protein -
FOG94_RS01690 391386..392006 + 621 WP_137281297.1 hypothetical protein -
FOG94_RS01695 391996..392910 - 915 WP_137281298.1 siderophore-interacting protein -
FOG94_RS01700 392897..393829 - 933 WP_137281403.1 iron-siderophore ABC transporter substrate-binding protein -
FOG94_RS01705 393949..395121 + 1173 WP_137281299.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10381.01 Da        Isoelectric Point: 9.5164

>T129018 WP_074803800.1 NZ_CP041694:390511-390789 [Cellulosimicrobium cellulans]
VTDVDGRWEVRLSPPAARMLYQLPPRLADAVIRFCDEPLASNPYRVTKALGAELAGQRAGYVGIGFRVLVRIDDDQRLVT
VMRMAYRADAYR

Download         Length: 279 bp

>T129018 NZ_CP041694:390511-390789 [Cellulosimicrobium cellulans]
GTGACCGACGTCGACGGTCGGTGGGAGGTGCGCCTGAGCCCACCGGCCGCACGCATGCTCTACCAGCTCCCACCACGCCT
GGCCGACGCCGTGATCCGCTTCTGCGACGAACCACTCGCGTCGAACCCCTACCGGGTGACGAAAGCGCTCGGGGCCGAGC
TCGCCGGCCAGCGCGCCGGGTACGTCGGGATCGGGTTCCGCGTCCTGGTCCGCATCGACGACGACCAGCGACTGGTCACC
GTGATGCGGATGGCCTACCGCGCCGACGCCTACCGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9739.93 Da        Isoelectric Point: 4.3671

>AT129018 WP_034653834.1 NZ_CP041694:390242-390514 [Cellulosimicrobium cellulans]
VQTYPMSEAKTNLSALVDEVESTHQPVTITRHGKAAAVLIAPEDLATLMETLAWLSDPDHAAEMAEAEEAVAQGRTLSLA
EVREQLASRR

Download         Length: 273 bp

>AT129018 NZ_CP041694:390242-390514 [Cellulosimicrobium cellulans]
GTGCAGACCTATCCCATGAGCGAAGCGAAAACCAACCTGTCCGCCCTGGTCGACGAGGTGGAGAGCACCCACCAACCGGT
GACGATCACCCGTCACGGGAAGGCGGCTGCGGTGCTGATCGCGCCAGAAGACCTGGCGACGCTCATGGAGACGCTTGCAT
GGCTGTCCGACCCTGACCACGCGGCCGAGATGGCCGAGGCCGAGGAGGCGGTGGCGCAGGGCCGCACCCTGAGCCTCGCC
GAGGTGCGCGAGCAGCTCGCCTCGCGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G7ISR9

Antitoxin

Source ID Structure
AlphaFold DB A0A085LF15

References