Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4661162..4661793 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS21270 Protein ID WP_143988036.1
Coordinates 4661416..4661793 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS21265 Protein ID WP_143988035.1
Coordinates 4661162..4661419 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS21240 4656810..4657259 - 450 WP_143989000.1 MarR family transcriptional regulator -
FOE78_RS21245 4657335..4657853 - 519 WP_143988031.1 MarR family transcriptional regulator -
FOE78_RS21250 4657993..4659267 + 1275 WP_143988032.1 MFS transporter -
FOE78_RS21255 4659350..4660705 + 1356 WP_143988033.1 DUF3327 domain-containing protein -
FOE78_RS21260 4660799..4661131 + 333 WP_143988034.1 hypothetical protein -
FOE78_RS21265 4661162..4661419 + 258 WP_143988035.1 hypothetical protein Antitoxin
FOE78_RS21270 4661416..4661793 + 378 WP_143988036.1 type II toxin-antitoxin system VapC family toxin Toxin
FOE78_RS21275 4661795..4662586 - 792 WP_143988037.1 DUF3027 domain-containing protein -
FOE78_RS21280 4662683..4664101 + 1419 WP_143988038.1 MFS transporter -
FOE78_RS21285 4664028..4665284 - 1257 WP_143988039.1 tellurite resistance/C4-dicarboxylate transporter family protein -
FOE78_RS21290 4665177..4665518 + 342 WP_143988040.1 ferredoxin family protein -
FOE78_RS21295 4665547..4666398 + 852 WP_143988041.1 polyphosphate kinase 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13746.85 Da        Isoelectric Point: 6.3266

>T129010 WP_143988036.1 NZ_CP041692:4661416-4661793 [Microlunatus sp. KUDC0627]
MIILDTSVLIDHLRGVADARRAMTSAVERGDLLAASVLTKVEVLAGMRAGEETQTRILLDSLRWVEVTDAIAERAGALAG
HFLRSHPGVDPVDYVIAATAQQLNARLWTMNLKHFPMFGDLQHPY

Download         Length: 378 bp

>T129010 NZ_CP041692:4661416-4661793 [Microlunatus sp. KUDC0627]
ATGATCATTCTCGACACTTCGGTCCTGATCGATCACCTTCGCGGCGTCGCCGATGCCCGGCGAGCCATGACCTCGGCGGT
TGAGCGTGGTGACTTGCTGGCCGCGTCGGTCCTGACGAAGGTCGAGGTTCTTGCCGGGATGCGTGCCGGCGAGGAGACAC
AAACTCGGATCTTGTTGGACAGTCTGCGCTGGGTCGAGGTCACCGATGCCATCGCCGAACGGGCCGGCGCCCTGGCCGGC
CACTTCCTGAGATCGCATCCTGGAGTCGATCCGGTTGACTACGTGATCGCTGCTACTGCTCAACAGCTGAACGCCCGGCT
CTGGACGATGAACCTCAAGCACTTCCCGATGTTTGGTGATCTGCAGCACCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9621.71 Da        Isoelectric Point: 4.8227

>AT129010 WP_143988035.1 NZ_CP041692:4661162-4661419 [Microlunatus sp. KUDC0627]
MSHRTQITLADEQYERLLTESSRSGLGLAELVRRAIDQTYGCNDVAKVLQALDLSYASWSEEGDRGEVYVESLRQGMARR
LEATR

Download         Length: 258 bp

>AT129010 NZ_CP041692:4661162-4661419 [Microlunatus sp. KUDC0627]
ATGTCGCACCGGACCCAGATTACGCTCGCCGACGAGCAGTACGAACGACTCCTCACCGAGTCGAGCCGCAGCGGCCTCGG
TCTCGCCGAGTTGGTCCGTCGGGCCATCGATCAAACCTACGGGTGCAACGATGTGGCTAAGGTCCTGCAGGCTCTGGACC
TCAGCTATGCAAGTTGGTCCGAGGAAGGTGACCGCGGCGAGGTGTACGTCGAGAGTCTCCGCCAGGGTATGGCCCGCCGG
CTCGAAGCGACTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References