Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4336750..4337426 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS19665 Protein ID WP_143987784.1
Coordinates 4336750..4337178 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS19670 Protein ID WP_143987785.1
Coordinates 4337175..4337426 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS19640 4332469..4333947 - 1479 WP_143987779.1 zf-HC2 domain-containing protein -
FOE78_RS19645 4333944..4334576 - 633 WP_143987780.1 RNA polymerase sigma factor SigE -
FOE78_RS19650 4334808..4335698 - 891 WP_143987781.1 4-hydroxy-tetrahydrodipicolinate synthase -
FOE78_RS19655 4335715..4335936 - 222 WP_143987782.1 biotin/lipoyl-binding carrier protein -
FOE78_RS19660 4336009..4336749 + 741 WP_143987783.1 class I SAM-dependent methyltransferase -
FOE78_RS19665 4336750..4337178 - 429 WP_143987784.1 PIN domain-containing protein Toxin
FOE78_RS19670 4337175..4337426 - 252 WP_143987785.1 antitoxin Antitoxin
FOE78_RS19675 4337493..4338722 - 1230 WP_143987786.1 glucose-1-phosphate adenylyltransferase -
FOE78_RS19680 4338829..4340028 + 1200 WP_143988954.1 glycogen synthase -
FOE78_RS19685 4340038..4340736 + 699 WP_210414684.1 phosphoribosyltransferase -
FOE78_RS19690 4340780..4341190 - 411 WP_143987787.1 MarR family transcriptional regulator -
FOE78_RS19695 4341266..4341721 + 456 WP_143987788.1 MarR family winged helix-turn-helix transcriptional regulator -
FOE78_RS19700 4341775..4341942 - 168 WP_091521298.1 DUF3117 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 14984.21 Da        Isoelectric Point: 6.0606

>T129008 WP_143987784.1 NZ_CP041692:c4337178-4336750 [Microlunatus sp. KUDC0627]
VKIVDINVLIYAINSADRNHRAAAGWLAAALQGSDTVGFSWSTILGFVRICTNPAAMQHPLTVEQAFDAVQSWLASPKAV
VLEPTARHLMIMKGLLVERGTAANLTSDAHLAALAIEYGGSVATFDRDVEALGVTVTIPTAS

Download         Length: 429 bp

>T129008 NZ_CP041692:c4337178-4336750 [Microlunatus sp. KUDC0627]
GTGAAGATCGTCGACATCAACGTGCTGATCTATGCCATCAATTCAGCCGACAGGAATCACCGGGCCGCCGCCGGCTGGTT
GGCTGCCGCGCTGCAGGGATCCGACACGGTCGGCTTCAGTTGGTCGACGATTCTCGGCTTCGTTCGAATCTGCACCAACC
CGGCCGCGATGCAGCACCCGCTGACGGTCGAGCAGGCCTTTGATGCGGTCCAGAGCTGGCTGGCCAGTCCGAAGGCTGTC
GTGCTGGAGCCGACGGCTCGGCACCTGATGATCATGAAGGGTCTGCTGGTTGAGCGAGGTACGGCGGCCAATCTGACCTC
CGACGCCCATCTGGCCGCGCTGGCGATCGAGTACGGCGGATCCGTGGCGACCTTCGATCGCGACGTCGAGGCCCTCGGTG
TGACCGTGACGATCCCTACCGCGTCTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9214.60 Da        Isoelectric Point: 4.8483

>AT129008 WP_143987785.1 NZ_CP041692:c4337426-4337175 [Microlunatus sp. KUDC0627]
MRTTVTLESEVEVRLRALMKERGIGFKEAINSALRAGLDLDPVVDLEFPSYDLGRPLVDLSHASRLAAAMEDEEVLRKMS
AGR

Download         Length: 252 bp

>AT129008 NZ_CP041692:c4337426-4337175 [Microlunatus sp. KUDC0627]
ATGCGCACGACGGTGACACTGGAGTCCGAGGTCGAGGTTCGGTTGCGCGCCCTGATGAAGGAGCGCGGGATCGGCTTCAA
GGAAGCGATCAACAGCGCCCTGCGCGCCGGTCTCGACCTCGACCCCGTTGTTGATCTTGAGTTTCCGAGCTATGACCTGG
GGCGACCCCTGGTCGATCTGAGTCACGCCTCCCGCCTCGCCGCGGCCATGGAGGACGAAGAGGTTCTGCGAAAGATGTCG
GCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References