Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 4137350..4138014 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS18645 Protein ID WP_210414664.1
Coordinates 4137350..4137715 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS18650 Protein ID WP_143987618.1
Coordinates 4137745..4138014 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS18620 4132962..4134311 - 1350 WP_210415047.1 carotenoid oxygenase family protein -
FOE78_RS18625 4134399..4134956 + 558 WP_143987613.1 PadR family transcriptional regulator -
FOE78_RS18630 4134961..4136415 + 1455 WP_168207283.1 GuaB1 family IMP dehydrogenase-related protein -
FOE78_RS18635 4136423..4136917 - 495 WP_143987615.1 SRPBCC family protein -
FOE78_RS18640 4136889..4137245 - 357 WP_143987616.1 metalloregulator ArsR/SmtB family transcription factor -
FOE78_RS18645 4137350..4137715 - 366 WP_210414664.1 PIN domain-containing protein Toxin
FOE78_RS18650 4137745..4138014 - 270 WP_143987618.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOE78_RS18655 4138087..4138362 - 276 WP_143987619.1 DUF2277 domain-containing protein -
FOE78_RS18660 4138418..4139956 - 1539 WP_143987620.1 DHA2 family efflux MFS transporter permease subunit -
FOE78_RS18665 4140082..4141566 - 1485 WP_143987621.1 DHA2 family efflux MFS transporter permease subunit -
FOE78_RS18670 4141539..4142105 - 567 WP_210415048.1 helix-turn-helix transcriptional regulator -
FOE78_RS18675 4142544..4142939 - 396 WP_143987623.1 cytochrome c oxidase subunit 4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-106)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13603.46 Da        Isoelectric Point: 4.5944

>T129006 WP_210414664.1 NZ_CP041692:c4137715-4137350 [Microlunatus sp. KUDC0627]
MLHTEQDSDALENWLPLDVDWLSSELAWTEVLRATRRIDEDWLPEAMNLLRMLDLIPVTRPVLERAALIAAPVLRSPDAI
HLATAELVRHGLTAFVSYDDRLDSAARAAGHPTFRPRDPSG

Download         Length: 366 bp

>T129006 NZ_CP041692:c4137715-4137350 [Microlunatus sp. KUDC0627]
TTGCTGCACACCGAGCAAGACTCGGATGCGTTGGAGAACTGGTTGCCGCTCGACGTCGATTGGCTGAGCAGCGAACTTGC
CTGGACTGAGGTCCTGCGTGCGACCCGGCGAATCGATGAGGATTGGCTGCCGGAGGCGATGAATCTGTTGCGCATGTTGG
ATCTGATTCCGGTCACCCGGCCGGTTCTCGAACGTGCCGCACTGATCGCCGCGCCGGTGCTGCGCAGTCCCGATGCCATT
CATCTGGCTACCGCCGAACTGGTGCGTCACGGGCTCACCGCGTTCGTCAGCTATGACGATCGGTTGGATTCTGCCGCGCG
GGCAGCGGGTCATCCAACGTTCCGTCCGCGCGACCCGAGCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9803.21 Da        Isoelectric Point: 10.3509

>AT129006 WP_143987618.1 NZ_CP041692:c4138014-4137745 [Microlunatus sp. KUDC0627]
MERIGVRELRQHATRYLALVKAGETVEVTDRGELVARLVPVTVAETVRDELIRAGQLAPAAQPRGRVRRRPATSGMTTAE
ALDLERGDQ

Download         Length: 270 bp

>AT129006 NZ_CP041692:c4138014-4137745 [Microlunatus sp. KUDC0627]
ATGGAGCGTATTGGCGTGCGGGAGCTGCGGCAACACGCGACCCGGTATCTGGCGTTGGTCAAGGCGGGGGAGACAGTTGA
GGTGACTGATCGAGGGGAGCTCGTCGCCCGGTTGGTTCCAGTCACCGTCGCCGAAACGGTCCGCGATGAACTCATTCGTG
CTGGGCAACTGGCACCGGCCGCGCAGCCGCGTGGACGCGTGCGCAGGCGACCTGCTACCTCGGGGATGACCACTGCGGAG
GCGCTCGACCTTGAACGCGGTGACCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References