Detailed information of TA system TA129003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2613692..2614224
• Replicon: chromosome
• Accession: NZ_CP041692
• Organism: Microlunatus sp. KUDC0627

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FOE78_RS11790
• Protein ID: WP_143986457.1
• Coordinates: 2613898..2614224 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FOE78_RS11785
• Protein ID: WP_143986456.1
• Coordinates: 2613692..2613901 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOE78_RS11780	2612476..2613450	+	975	WP_143986455.1	PAC2 family protein	-
FOE78_RS11785	2613692..2613901	+	210	WP_143986456.1	DUF3018 family protein	Antitoxin
FOE78_RS11790	2613898..2614224	+	327	WP_143986457.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FOE78_RS11795	2614580..2615452	+	873	WP_143986458.1	acyl-CoA thioesterase II	-
FOE78_RS23860	2615494..2615763	+	270	WP_210414539.1	ANTAR domain-containing protein	-
FOE78_RS11805	2615786..2616523	+	738	WP_143986459.1	GAF and ANTAR domain-containing protein	-
FOE78_RS11810	2616734..2617072	+	339	WP_168207489.1	hypothetical protein	-
FOE78_RS11815	2617094..2618806	-	1713	WP_143986461.1	GAF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (4-67)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11651.47 Da
• Isoelectric Point: 8.7150

>T129003 WP_143986457.1 NZ_CP041692:2613898-2614224 [Microlunatus sp. KUDC0627]
VNRGELWTVAGGVYASKPRPALIVQDEVFDATASVTVAPLTSTLTDAPLLRIRIGPSALSGLERDSEVMIDKLTTVRRTS
VANRLGRLTAEQLTEVERAMMAFLGLAR

Nucleotide

• Length: 327 bp

>T129003 NZ_CP041692:2613898-2614224 [Microlunatus sp. KUDC0627]
GTGAACCGCGGGGAGCTCTGGACGGTCGCCGGCGGGGTCTACGCGTCCAAGCCGCGGCCGGCGCTGATCGTGCAAGACGA
GGTCTTCGACGCCACGGCCTCGGTGACGGTGGCTCCGCTGACCAGCACACTGACTGATGCGCCGCTGCTGCGGATCCGTA
TCGGCCCCTCGGCGCTGTCCGGACTGGAGCGCGACAGCGAGGTCATGATCGACAAACTGACTACGGTGCGGCGGACGAGT
GTTGCCAACCGTCTGGGGCGGCTGACAGCTGAACAGCTCACCGAAGTCGAACGCGCCATGATGGCCTTCCTGGGACTCGC
CAGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8064.89 Da
• Isoelectric Point: 5.1037

>AT129003 WP_143986456.1 NZ_CP041692:2613692-2613901 [Microlunatus sp. KUDC0627]
MSVRDRVSSYRRRMRERGYRPVQIWVPDVRTERFAAEAHRQAALVAAADRTGDDQDFIEAVSAPWDDEE

Nucleotide

• Length: 210 bp

>AT129003 NZ_CP041692:2613692-2613901 [Microlunatus sp. KUDC0627]
ATGTCAGTCAGGGACCGGGTCAGCAGCTATCGGCGCCGGATGCGTGAGCGGGGCTACCGCCCGGTGCAGATCTGGGTTCC
CGATGTGCGTACCGAACGATTCGCCGCGGAGGCGCACCGCCAGGCCGCGCTGGTGGCTGCCGCGGATCGAACTGGCGACG
ATCAAGACTTCATCGAGGCCGTATCAGCGCCGTGGGATGACGAGGAGTGA