Detailed information of TA system TA129002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 2528085..2528728
• Replicon: chromosome
• Accession: NZ_CP041692
• Organism: Microlunatus sp. KUDC0627

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOE78_RS11420
• Protein ID: WP_210414929.1
• Coordinates: 2528312..2528728 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOE78_RS11415
• Protein ID: WP_143986395.1
• Coordinates: 2528085..2528303 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOE78_RS11380	2523796..2524446	+	651	WP_143986390.1	hydroxylase	-
FOE78_RS11385	2524480..2524716	-	237	WP_143986391.1	DUF3107 domain-containing protein	-
FOE78_RS11390	2524775..2525242	-	468	WP_143986392.1	FHA domain-containing protein	-
FOE78_RS11395	2525239..2525898	-	660	WP_143988746.1	TetR/AcrR family transcriptional regulator	-
FOE78_RS11400	2525948..2526379	-	432	WP_143986393.1	type II toxin-antitoxin system VapC family toxin	-
FOE78_RS11405	2526376..2526642	-	267	WP_143986394.1	type II toxin-antitoxin system VapB family antitoxin	-
FOE78_RS11410	2526795..2527967	+	1173	WP_143988747.1	adenylyltransferase/sulfurtransferase MoeZ	-
FOE78_RS11415	2528085..2528303	+	219	WP_143986395.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOE78_RS11420	2528312..2528728	+	417	WP_210414929.1	hypothetical protein	Toxin
FOE78_RS11425	2528798..2529295	+	498	WP_143986397.1	CAP domain-containing protein	-
FOE78_RS11430	2529327..2530082	-	756	WP_143986398.1	SDR family oxidoreductase	-
FOE78_RS11435	2530094..2530960	-	867	WP_143986399.1	NAD(P)-binding domain-containing protein	-
FOE78_RS11440	2530953..2531753	-	801	WP_143986400.1	sugar phosphate isomerase/epimerase	-
FOE78_RS11445	2531750..2533183	-	1434	WP_143986401.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (4-45)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15687.52 Da
• Isoelectric Point: 4.9628

>T129002 WP_210414929.1 NZ_CP041692:2528312-2528728 [Microlunatus sp. KUDC0627]
MLDSTAIWRIQRSRELSDGWADEADVGALGSCLPQRLEFRRSARNLDEFEQMSGMFSELYPDVPVPKVAWSWVDSAQFRL
ASRGRHQALSVVDWLVCATAAHHDLVVLHDDRDFHTASELLPDLREHNVHDLPPAGDR

Nucleotide

• Length: 417 bp

>T129002 NZ_CP041692:2528312-2528728 [Microlunatus sp. KUDC0627]
TTGCTCGATTCGACCGCGATCTGGCGCATCCAACGAAGCCGTGAGTTGTCCGACGGCTGGGCCGACGAGGCCGATGTCGG
AGCTCTGGGGTCTTGCCTGCCGCAGCGGTTGGAATTTCGGCGATCCGCGCGGAATCTGGACGAGTTCGAGCAGATGTCCG
GCATGTTCTCCGAACTCTACCCGGACGTTCCGGTACCGAAAGTTGCCTGGTCCTGGGTGGATTCAGCGCAATTCCGGCTG
GCCTCGCGGGGACGACATCAAGCCCTGTCGGTGGTGGACTGGCTGGTCTGCGCGACGGCCGCACATCACGATCTCGTAGT
TCTCCACGACGACCGGGATTTCCACACGGCCTCCGAGTTACTGCCCGACCTGCGCGAGCACAACGTCCACGATCTCCCGC
CAGCAGGCGACAGGTAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8515.44 Da
• Isoelectric Point: 4.8485

>AT129002 WP_143986395.1 NZ_CP041692:2528085-2528303 [Microlunatus sp. KUDC0627]
MASTQIDIDDDALDAAMRLAGVRTKKEMVNLALREYAQRRARSEARLRYFAQAQSWDDEDFWRRHEAEKDPE

Nucleotide

• Length: 219 bp

>AT129002 NZ_CP041692:2528085-2528303 [Microlunatus sp. KUDC0627]
ATGGCGTCGACACAGATCGACATCGACGACGACGCACTGGACGCCGCGATGCGCCTGGCGGGAGTGCGAACCAAGAAGGA
AATGGTCAACCTCGCGCTACGAGAGTACGCACAGCGGCGTGCCCGAAGCGAGGCGCGGTTACGGTACTTCGCCCAAGCCC
AATCGTGGGACGACGAGGACTTCTGGCGCCGCCACGAGGCGGAGAAGGATCCGGAGTGA