Detailed information of TA system TA129001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2525948..2526642
• Replicon: chromosome
• Accession: NZ_CP041692
• Organism: Microlunatus sp. KUDC0627

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOE78_RS11400
• Protein ID: WP_143986393.1
• Coordinates: 2525948..2526379 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOE78_RS11405
• Protein ID: WP_143986394.1
• Coordinates: 2526376..2526642 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOE78_RS11370	2521198..2522076	+	879	WP_210414928.1	WYL domain-containing protein	-
FOE78_RS11375	2522000..2523697	-	1698	WP_143986389.1	DEAD/DEAH box helicase	-
FOE78_RS11380	2523796..2524446	+	651	WP_143986390.1	hydroxylase	-
FOE78_RS11385	2524480..2524716	-	237	WP_143986391.1	DUF3107 domain-containing protein	-
FOE78_RS11390	2524775..2525242	-	468	WP_143986392.1	FHA domain-containing protein	-
FOE78_RS11395	2525239..2525898	-	660	WP_143988746.1	TetR/AcrR family transcriptional regulator	-
FOE78_RS11400	2525948..2526379	-	432	WP_143986393.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOE78_RS11405	2526376..2526642	-	267	WP_143986394.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOE78_RS11410	2526795..2527967	+	1173	WP_143988747.1	adenylyltransferase/sulfurtransferase MoeZ	-
FOE78_RS11415	2528085..2528303	+	219	WP_143986395.1	type II toxin-antitoxin system VapB family antitoxin	-
FOE78_RS11420	2528312..2528728	+	417	WP_210414929.1	hypothetical protein	-
FOE78_RS11425	2528798..2529295	+	498	WP_143986397.1	CAP domain-containing protein	-
FOE78_RS11430	2529327..2530082	-	756	WP_143986398.1	SDR family oxidoreductase	-
FOE78_RS11435	2530094..2530960	-	867	WP_143986399.1	NAD(P)-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-137)

Antitoxin

• Antitoxin VapB-like (2-87)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16049.00 Da
• Isoelectric Point: 5.2273

>T129001 WP_143986393.1 NZ_CP041692:c2526379-2525948 [Microlunatus sp. KUDC0627]
VIVDTSAVIAILFFEPEADEFFDHLASERAVMSAASYVECSVVTDRATTDRFRRPVNPSDLRAYTRRAVDRIVTDLDILI
SPVTREQADLARTAHRLYGAGSGSPARLNFGDCFSYALAKDTDQPLLYKGTDFDHTDVRIFRR

Nucleotide

• Length: 432 bp

>T129001 NZ_CP041692:c2526379-2525948 [Microlunatus sp. KUDC0627]
GTGATCGTCGACACATCAGCGGTGATCGCGATCCTGTTCTTCGAGCCGGAGGCTGATGAGTTCTTCGATCATCTCGCCTC
CGAGCGTGCCGTCATGTCGGCAGCGAGCTATGTCGAATGCTCGGTAGTGACTGATCGGGCGACGACGGACAGGTTTCGTC
GTCCGGTCAATCCCTCGGATCTTCGGGCCTACACTCGTCGAGCTGTCGACCGAATCGTCACAGATCTCGACATCTTGATC
TCCCCGGTCACCCGTGAGCAGGCCGATCTGGCCCGTACCGCTCATCGGCTCTACGGCGCCGGCTCCGGCAGTCCGGCCAG
GCTCAACTTCGGCGACTGCTTCTCCTACGCCCTGGCCAAGGACACCGACCAGCCGCTGCTCTACAAGGGCACCGACTTCG
ACCACACCGACGTCCGCATCTTCCGACGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10169.23 Da
• Isoelectric Point: 4.4691

>AT129001 WP_143986394.1 NZ_CP041692:c2526642-2526376 [Microlunatus sp. KUDC0627]
VSLNIKNERTHALVRELAELTGQSQTSAVEDAVRRRLEELRGEADREERIERLLADLKKARDEFGPIEESEDWDPRGDFL
YDAYGVPK

Nucleotide

• Length: 267 bp

>AT129001 NZ_CP041692:c2526642-2526376 [Microlunatus sp. KUDC0627]
GTGAGCCTCAACATCAAGAACGAGCGCACCCACGCCTTGGTCCGTGAACTGGCCGAGCTGACCGGACAGAGCCAGACCTC
GGCAGTGGAGGATGCGGTACGGCGCCGACTCGAGGAACTGCGCGGGGAAGCGGATCGCGAAGAGCGGATCGAGCGACTGC
TCGCCGATCTGAAGAAGGCGCGCGACGAGTTCGGGCCCATCGAGGAATCAGAGGACTGGGACCCACGCGGAGACTTCCTG
TACGACGCGTACGGAGTTCCGAAGTGA