Detailed information of TA system TA129000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2507421..2508045
• Replicon: chromosome
• Accession: NZ_CP041692
• Organism: Microlunatus sp. KUDC0627

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOE78_RS11310
• Protein ID: WP_168207479.1
• Coordinates: 2507421..2507831 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOE78_RS11315
• Protein ID: WP_168207480.1
• Coordinates: 2507833..2508045 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOE78_RS11285	2502639..2502878	+	240	WP_143986374.1	hypothetical protein	-
FOE78_RS11290	2502945..2504363	+	1419	WP_143986375.1	wax ester/triacylglycerol synthase family O-acyltransferase	-
FOE78_RS11295	2504366..2504863	+	498	WP_143986376.1	hypothetical protein	-
FOE78_RS11300	2504923..2505741	+	819	WP_143986377.1	Ku protein	-
FOE78_RS11305	2505783..2507408	+	1626	WP_143986378.1	L-glutamate gamma-semialdehyde dehydrogenase	-
FOE78_RS11310	2507421..2507831	-	411	WP_168207479.1	PIN domain-containing protein	Toxin
FOE78_RS11315	2507833..2508045	-	213	WP_168207480.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOE78_RS11320	2508101..2508571	-	471	WP_168207481.1	DUF2505 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-39)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15236.35 Da
• Isoelectric Point: 4.5264

>T129000 WP_168207479.1 NZ_CP041692:c2507831-2507421 [Microlunatus sp. KUDC0627]
MAELVDSSVWIDYLRNLPSAATAHLTEVLTARPEDLLGCPPVRMELSVPSEEMTRRRTLAIYDQLDSVHVMDEDFDSAAE
IFRDVRSSGHTVRSMVDCLIAALAERSSVRLVHADIDYIRIQAVRPNLATLSLLQD

Nucleotide

• Length: 411 bp

>T129000 NZ_CP041692:c2507831-2507421 [Microlunatus sp. KUDC0627]
ATGGCCGAACTGGTCGACTCGTCGGTTTGGATCGACTATCTGCGTAACCTGCCATCAGCCGCGACGGCACACTTGACCGA
GGTGCTGACCGCCCGACCCGAGGATCTGCTCGGCTGTCCGCCGGTGCGCATGGAGCTGAGCGTGCCGTCGGAAGAGATGA
CGCGGCGGCGCACTCTCGCGATCTACGACCAACTCGATTCCGTCCACGTCATGGACGAAGACTTCGACAGTGCCGCCGAG
ATATTTCGGGATGTCCGCAGCTCGGGCCACACGGTCCGGTCGATGGTCGACTGTCTGATCGCAGCTTTGGCGGAGCGATC
CAGCGTGAGGCTGGTCCACGCGGACATCGACTACATCCGCATCCAAGCTGTTCGACCGAACCTTGCCACGTTGAGTTTGC
TCCAGGATTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8193.34 Da
• Isoelectric Point: 4.8096

>AT129000 WP_168207480.1 NZ_CP041692:c2508045-2507833 [Microlunatus sp. KUDC0627]
MTRTNIDIDDELVETVMKQNHLKTKREAVDFALRRTVRRMPTTEEFLALRGIGFPMSNDEIEGLSEPKDW

Nucleotide

• Length: 213 bp

>AT129000 NZ_CP041692:c2508045-2507833 [Microlunatus sp. KUDC0627]
ATGACGCGCACCAACATCGACATCGACGATGAGCTGGTCGAGACGGTGATGAAACAGAATCACCTCAAGACCAAGCGGGA
AGCCGTCGACTTCGCGCTGCGCAGAACGGTACGGAGAATGCCGACCACGGAAGAGTTTCTCGCACTGAGAGGCATCGGAT
TCCCGATGTCGAACGATGAGATCGAGGGCCTCTCCGAACCCAAGGACTGGTGA