Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2317479..2318143 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS10440 Protein ID WP_143986226.1
Coordinates 2317479..2317907 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS10445 Protein ID WP_143986227.1
Coordinates 2317904..2318143 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS10410 2312642..2313196 + 555 WP_210414995.1 ribosome recycling factor -
FOE78_RS10415 2313353..2314237 + 885 WP_143986221.1 phosphatidate cytidylyltransferase -
FOE78_RS10420 2314637..2315071 - 435 WP_143986222.1 ester cyclase -
FOE78_RS10425 2315211..2315828 + 618 WP_143986223.1 TetR/AcrR family transcriptional regulator -
FOE78_RS10430 2316037..2316555 + 519 WP_143986224.1 hypothetical protein -
FOE78_RS10435 2316564..2317397 - 834 WP_143986225.1 DUF72 domain-containing protein -
FOE78_RS10440 2317479..2317907 - 429 WP_143986226.1 PIN domain-containing protein Toxin
FOE78_RS10445 2317904..2318143 - 240 WP_143986227.1 ribbon-helix-helix protein, CopG family Antitoxin
FOE78_RS10450 2318275..2319399 + 1125 WP_143986228.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
FOE78_RS10455 2319407..2320111 - 705 WP_143986229.1 class I SAM-dependent methyltransferase -
FOE78_RS10460 2320141..2320914 - 774 WP_143986230.1 DUF899 domain-containing protein -
FOE78_RS10465 2321264..2322226 + 963 WP_168207463.1 hypothetical protein -
FOE78_RS10470 2322316..2322774 - 459 WP_143986232.1 MaoC family dehydratase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15718.59 Da        Isoelectric Point: 4.2401

>T128999 WP_143986226.1 NZ_CP041692:c2317907-2317479 [Microlunatus sp. KUDC0627]
VTALLDVNVLLALFDSDHVGHATAWEWLDAEIDDGWASCAITENGFIRIISQPRYPHPIPPAQAIELLAEATATEQHSFW
ASDVTVTSRDHIDPSHLLRSPQITDSYLLSLAVEHDGRLVTFDQSIELDSVPRATAEHLMVL

Download         Length: 429 bp

>T128999 NZ_CP041692:c2317907-2317479 [Microlunatus sp. KUDC0627]
GTGACCGCGCTCCTCGACGTAAATGTCCTGTTGGCACTCTTCGACTCCGACCACGTCGGCCACGCCACGGCCTGGGAGTG
GCTCGACGCGGAGATCGACGATGGTTGGGCAAGTTGCGCGATCACCGAGAACGGATTCATCAGGATCATCAGCCAGCCCA
GGTATCCCCATCCGATTCCGCCGGCGCAGGCCATCGAGTTGCTGGCGGAGGCAACCGCTACCGAACAGCATTCCTTCTGG
GCAAGTGACGTCACCGTCACGAGTCGAGATCACATCGACCCGTCGCATCTGCTGAGGTCCCCGCAGATCACGGACAGCTA
CCTCCTGTCGCTCGCCGTCGAGCACGATGGCCGGCTGGTCACCTTCGACCAGTCGATCGAACTCGATTCCGTTCCGCGAG
CCACTGCCGAACACCTGATGGTGTTGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8899.88 Da        Isoelectric Point: 6.2270

>AT128999 WP_143986227.1 NZ_CP041692:c2318143-2317904 [Microlunatus sp. KUDC0627]
MRTTLTVDDDVLRAVKERAAREHRTAGEVLSELARQSLTRSATHSARTEEARYGFRPLPHRGGVVTNELIDDIRDDEAL

Download         Length: 240 bp

>AT128999 NZ_CP041692:c2318143-2317904 [Microlunatus sp. KUDC0627]
ATGCGCACAACGTTGACGGTAGATGATGATGTCCTGCGGGCGGTGAAGGAACGAGCCGCGCGGGAACACCGAACCGCCGG
CGAGGTCCTGTCGGAGCTCGCGAGGCAGTCGCTCACCCGATCAGCTACCCACTCCGCGCGGACCGAAGAAGCCCGTTACG
GCTTCCGTCCGCTACCACACCGCGGCGGAGTGGTGACCAATGAACTCATCGACGACATCCGCGACGACGAGGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References