Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2257255..2257790 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FOE78_RS10140 Protein ID WP_143986183.1
Coordinates 2257255..2257581 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FOE78_RS10145 Protein ID WP_168207458.1
Coordinates 2257578..2257790 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS10120 2252667..2253107 - 441 WP_143986179.1 DUF393 domain-containing protein -
FOE78_RS10125 2253112..2254068 - 957 WP_143986180.1 hypothetical protein -
FOE78_RS10130 2254178..2256265 + 2088 WP_210414910.1 DNA primase -
FOE78_RS10135 2256346..2257245 + 900 WP_143986182.1 sigma-70 family RNA polymerase sigma factor -
FOE78_RS10140 2257255..2257581 - 327 WP_143986183.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOE78_RS10145 2257578..2257790 - 213 WP_168207458.1 antitoxin MazE family protein Antitoxin
FOE78_RS10160 2258171..2258824 - 654 WP_143986185.1 hypothetical protein -
FOE78_RS10165 2258865..2260331 - 1467 WP_143986186.1 trehalose-6-phosphate synthase -
FOE78_RS10170 2260457..2261320 + 864 WP_143986187.1 trehalose-phosphatase -
FOE78_RS10175 2261349..2262563 - 1215 WP_143986188.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-101)

Antitoxin

Antitoxin MazE-like

(6-67)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11881.66 Da        Isoelectric Point: 6.3172

>T128998 WP_143986183.1 NZ_CP041692:c2257581-2257255 [Microlunatus sp. KUDC0627]
VKRGDIWIGAGTGYASKPRPVLVIQNDRFDATDSVLVVPFTSADADAPLARLQVEPDATNGLDKRSWLQIDKLGPVKRVN
LRSRLGELDEDLLRQLTPMITLFLGLGQ

Download         Length: 327 bp

>T128998 NZ_CP041692:c2257581-2257255 [Microlunatus sp. KUDC0627]
GTGAAGCGCGGCGACATCTGGATCGGCGCTGGGACGGGCTACGCCAGCAAACCCCGCCCGGTTCTGGTCATTCAGAATGA
CCGTTTCGACGCAACCGATTCAGTCCTGGTCGTTCCGTTCACCAGCGCCGACGCCGATGCGCCCCTGGCCAGGCTCCAGG
TCGAACCCGACGCCACCAACGGTCTGGACAAGCGGTCCTGGCTGCAGATTGACAAGCTCGGCCCGGTCAAGCGGGTGAAC
CTGCGCAGCCGCCTGGGCGAACTCGATGAAGATCTGCTCCGTCAGCTGACGCCGATGATCACCCTGTTCCTAGGGCTGGG
CCAATGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8140.10 Da        Isoelectric Point: 5.5977

>AT128998 WP_168207458.1 NZ_CP041692:c2257790-2257578 [Microlunatus sp. KUDC0627]
MGTSTERVRQHRERLRHRGMRPVQIWIPDVNAPGFAEEAHRQAMNIRNSPAEAEDQAWMEAMVAEVWDGE

Download         Length: 213 bp

>AT128998 NZ_CP041692:c2257790-2257578 [Microlunatus sp. KUDC0627]
ATGGGTACATCCACCGAACGCGTACGCCAACACCGCGAGCGCCTCCGCCACCGTGGCATGCGCCCGGTGCAGATCTGGAT
CCCCGACGTCAACGCCCCCGGCTTCGCCGAGGAAGCCCACCGCCAGGCCATGAACATCCGCAACTCCCCCGCCGAGGCGG
AGGACCAAGCCTGGATGGAGGCGATGGTCGCCGAGGTTTGGGATGGCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References