Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2185564..2186183 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS09805 Protein ID WP_143986123.1
Coordinates 2185564..2185971 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS09810 Protein ID WP_143986124.1
Coordinates 2185968..2186183 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS09790 2181816..2183180 + 1365 WP_143986120.1 DUF2029 domain-containing protein -
FOE78_RS09795 2183183..2184151 - 969 WP_143986121.1 phosphotransferase -
FOE78_RS09800 2184326..2185543 + 1218 WP_143986122.1 coproporphyrinogen III oxidase -
FOE78_RS09805 2185564..2185971 - 408 WP_143986123.1 PIN domain nuclease Toxin
FOE78_RS09810 2185968..2186183 - 216 WP_143986124.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOE78_RS09815 2186239..2187123 - 885 WP_143986125.1 DUF3097 domain-containing protein -
FOE78_RS09820 2187266..2188225 - 960 WP_168207451.1 MBL fold metallo-hydrolase -
FOE78_RS09825 2188346..2189398 + 1053 WP_143986127.1 heat-inducible transcriptional repressor HrcA -
FOE78_RS09830 2189449..2190630 + 1182 WP_143986128.1 molecular chaperone DnaJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15572.59 Da        Isoelectric Point: 6.4837

>T128997 WP_143986123.1 NZ_CP041692:c2185971-2185564 [Microlunatus sp. KUDC0627]
VSDTRYLIDTSALARFLRQQPATRGWERAARSGLIAICPIVELETLYSARSIEDRRRTMQRFREIFVSQFMPERAFERAD
SLQQELTQRGEHRSAGPVDLLVAATAELARLTLLHHDHDFDCIARVTGQPTEWFD

Download         Length: 408 bp

>T128997 NZ_CP041692:c2185971-2185564 [Microlunatus sp. KUDC0627]
GTGAGCGACACACGATATCTGATCGACACCAGCGCACTGGCGCGGTTTCTTCGCCAGCAACCAGCGACGCGCGGCTGGGA
ACGGGCCGCACGAAGCGGCCTGATCGCCATCTGCCCCATTGTCGAACTGGAGACCCTGTACAGCGCTCGGTCGATCGAGG
ACCGTAGGCGGACGATGCAGCGCTTCCGCGAGATTTTCGTGTCGCAGTTCATGCCCGAACGAGCATTCGAAAGGGCCGAC
TCCCTCCAACAGGAATTGACACAGCGCGGCGAACACCGCAGTGCCGGTCCGGTCGACCTGCTGGTGGCGGCGACCGCGGA
ACTGGCCCGGCTCACCCTGCTCCACCATGATCACGATTTCGATTGCATCGCTCGGGTGACCGGCCAGCCCACCGAATGGT
TCGACTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8127.32 Da        Isoelectric Point: 4.8151

>AT128997 WP_143986124.1 NZ_CP041692:c2186183-2185968 [Microlunatus sp. KUDC0627]
MTRTVIDLDDQLVAEVAEALGTKTKKDTVNTALREVLESRRRALALIQLRDEIEDGALDLDLLMDKKNYRR

Download         Length: 216 bp

>AT128997 NZ_CP041692:c2186183-2185968 [Microlunatus sp. KUDC0627]
ATGACTCGGACAGTGATCGACCTGGATGACCAACTGGTGGCCGAAGTTGCCGAAGCCCTCGGCACCAAGACCAAGAAGGA
CACGGTCAACACGGCGTTGCGGGAAGTCCTGGAGAGCCGCCGTCGCGCACTCGCACTGATTCAACTCCGTGACGAGATCG
AGGACGGCGCGCTCGACCTCGATCTCCTGATGGACAAGAAGAACTACCGTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References