Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1677836..1678452 Replicon chromosome
Accession NZ_CP041692
Organism Microlunatus sp. KUDC0627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOE78_RS07495 Protein ID WP_143985730.1
Coordinates 1677836..1678225 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOE78_RS07500 Protein ID WP_143985731.1
Coordinates 1678222..1678452 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOE78_RS23830 1673121..1673531 + 411 WP_210414873.1 hypothetical protein -
FOE78_RS07475 1673672..1675006 - 1335 WP_143988642.1 IS1380 family transposase -
FOE78_RS07480 1675186..1676217 + 1032 WP_143985727.1 hypothetical protein -
FOE78_RS07485 1676223..1677263 + 1041 WP_143985728.1 cation diffusion facilitator family transporter -
FOE78_RS07490 1677400..1677831 + 432 WP_143985729.1 type II 3-dehydroquinate dehydratase -
FOE78_RS07495 1677836..1678225 - 390 WP_143985730.1 type II toxin-antitoxin system VapC family toxin Toxin
FOE78_RS07500 1678222..1678452 - 231 WP_143985731.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOE78_RS07505 1678519..1679910 - 1392 WP_143985732.1 DUF2786 domain-containing protein -
FOE78_RS07510 1679991..1680668 - 678 WP_143985733.1 TetR family transcriptional regulator -
FOE78_RS07515 1680774..1681712 + 939 WP_143985734.1 SDR family oxidoreductase -
FOE78_RS07520 1681728..1682720 - 993 WP_143985735.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-129)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14533.49 Da        Isoelectric Point: 4.7105

>T128996 WP_143985730.1 NZ_CP041692:c1678225-1677836 [Microlunatus sp. KUDC0627]
VSRVLLDTHALLWWFTDDPRLSSAARSEIASIDNQVFVSAASAWEISTKQRLGKLDEVPEATERYPQLVALNGFTPLPVE
QRHALTAGSFDVVHRDPFDRMLAAQSKLESLPLVTKDPAFQLFEIETLW

Download         Length: 390 bp

>T128996 NZ_CP041692:c1678225-1677836 [Microlunatus sp. KUDC0627]
GTGAGCCGGGTTCTCCTCGACACCCATGCGCTGTTGTGGTGGTTCACCGACGACCCCAGGCTGTCGTCGGCGGCCCGTTC
CGAGATCGCTTCGATCGACAACCAGGTCTTTGTCAGTGCCGCGAGCGCATGGGAGATCTCGACAAAGCAGCGCCTGGGCA
AGCTCGACGAGGTGCCGGAGGCGACGGAGCGCTATCCGCAGCTCGTCGCGCTCAACGGGTTCACCCCACTGCCCGTCGAA
CAGCGGCACGCGCTGACAGCCGGCAGTTTCGATGTGGTCCATCGCGATCCGTTCGACCGCATGCTGGCCGCCCAGAGCAA
GCTCGAGTCGCTTCCGCTTGTGACCAAGGACCCGGCCTTCCAGCTGTTCGAGATCGAGACCCTCTGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8233.17 Da        Isoelectric Point: 4.2933

>AT128996 WP_143985731.1 NZ_CP041692:c1678452-1678222 [Microlunatus sp. KUDC0627]
MVTINVHDAKTHLSRLLERAHAGEEIILAKSGIPYARLVPLAPSEAREPGGLDGYLGESFFDSLPDSELDAWEGDS

Download         Length: 231 bp

>AT128996 NZ_CP041692:c1678452-1678222 [Microlunatus sp. KUDC0627]
ATGGTGACCATCAACGTCCACGACGCGAAGACTCATCTGTCCCGGCTGCTGGAACGCGCCCATGCCGGTGAGGAGATCAT
CCTCGCCAAGTCCGGCATCCCGTACGCGCGTCTGGTGCCCCTTGCTCCCAGCGAAGCGCGAGAGCCCGGGGGGCTCGACG
GCTACCTCGGCGAGTCGTTCTTCGACTCGCTGCCCGACTCCGAATTGGACGCTTGGGAAGGTGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References