Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1418153..1418668 Replicon chromosome
Accession NZ_CP041689
Organism Micrococcus luteus strain 10240

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag FOF50_RS06435 Protein ID WP_041103932.1
Coordinates 1418153..1418407 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag FOF50_RS06440 Protein ID WP_036340860.1
Coordinates 1418408..1418668 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOF50_RS06400 (FOF50_06430) 1413746..1414392 - 647 Protein_1260 aquaporin Z -
FOF50_RS06405 (FOF50_06435) 1414601..1414966 - 366 WP_231119488.1 NUDIX hydrolase -
FOF50_RS06410 (FOF50_06440) 1414976..1415257 - 282 WP_231119487.1 hypothetical protein -
FOF50_RS06415 (FOF50_06445) 1415495..1416220 + 726 WP_169577815.1 histidine phosphatase family protein -
FOF50_RS06420 (FOF50_06450) 1416217..1416759 + 543 WP_155932748.1 DUF3090 domain-containing protein -
FOF50_RS06425 (FOF50_06455) 1416759..1417541 + 783 WP_069941698.1 SCO1664 family protein -
FOF50_RS06430 (FOF50_06460) 1417585..1418151 - 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
FOF50_RS06435 (FOF50_06465) 1418153..1418407 - 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
FOF50_RS06440 (FOF50_06470) 1418408..1418668 - 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOF50_RS06445 (FOF50_06475) 1418854..1420257 + 1404 WP_155932746.1 GntP family permease -
FOF50_RS06450 (FOF50_06480) 1420287..1421441 + 1155 WP_155932744.1 glycerate kinase -
FOF50_RS11355 (FOF50_06485) 1421443..1421858 + 416 Protein_1271 phosphatidylinositol kinase -
FOF50_RS11665 (FOF50_06490) 1421969..1422214 - 246 Protein_1272 ATP-binding cassette domain-containing protein -
FOF50_RS06460 (FOF50_06495) 1422485..1423573 + 1089 WP_196773884.1 catalase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-84)

Antitoxin

(2-70)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T128990 WP_041103932.1 NZ_CP041689:c1418407-1418153 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T128990 NZ_CP041689:c1418407-1418153 [Micrococcus luteus]
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCAAGCGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGACGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGCCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT128990 WP_036340860.1 NZ_CP041689:c1418668-1418408 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT128990 NZ_CP041689:c1418668-1418408 [Micrococcus luteus]
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTAGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91


Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References