Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/YoeB-YefM |
Location | 1418153..1418668 | Replicon | chromosome |
Accession | NZ_CP041689 | ||
Organism | Micrococcus luteus strain 10240 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A4Y1LR91 |
Locus tag | FOF50_RS06435 | Protein ID | WP_041103932.1 |
Coordinates | 1418153..1418407 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A229HG25 |
Locus tag | FOF50_RS06440 | Protein ID | WP_036340860.1 |
Coordinates | 1418408..1418668 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOF50_RS06400 (FOF50_06430) | 1413746..1414392 | - | 647 | Protein_1260 | aquaporin Z | - |
FOF50_RS06405 (FOF50_06435) | 1414601..1414966 | - | 366 | WP_231119488.1 | NUDIX hydrolase | - |
FOF50_RS06410 (FOF50_06440) | 1414976..1415257 | - | 282 | WP_231119487.1 | hypothetical protein | - |
FOF50_RS06415 (FOF50_06445) | 1415495..1416220 | + | 726 | WP_169577815.1 | histidine phosphatase family protein | - |
FOF50_RS06420 (FOF50_06450) | 1416217..1416759 | + | 543 | WP_155932748.1 | DUF3090 domain-containing protein | - |
FOF50_RS06425 (FOF50_06455) | 1416759..1417541 | + | 783 | WP_069941698.1 | SCO1664 family protein | - |
FOF50_RS06430 (FOF50_06460) | 1417585..1418151 | - | 567 | WP_041103934.1 | mismatch-specific DNA-glycosylase | - |
FOF50_RS06435 (FOF50_06465) | 1418153..1418407 | - | 255 | WP_041103932.1 | Txe/YoeB family addiction module toxin | Toxin |
FOF50_RS06440 (FOF50_06470) | 1418408..1418668 | - | 261 | WP_036340860.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
FOF50_RS06445 (FOF50_06475) | 1418854..1420257 | + | 1404 | WP_155932746.1 | GntP family permease | - |
FOF50_RS06450 (FOF50_06480) | 1420287..1421441 | + | 1155 | WP_155932744.1 | glycerate kinase | - |
FOF50_RS11355 (FOF50_06485) | 1421443..1421858 | + | 416 | Protein_1271 | phosphatidylinositol kinase | - |
FOF50_RS11665 (FOF50_06490) | 1421969..1422214 | - | 246 | Protein_1272 | ATP-binding cassette domain-containing protein | - |
FOF50_RS06460 (FOF50_06495) | 1422485..1423573 | + | 1089 | WP_196773884.1 | catalase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9996.33 Da Isoelectric Point: 7.3149
>T128990 WP_041103932.1 NZ_CP041689:c1418407-1418153 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY
Download Length: 255 bp
>T128990 NZ_CP041689:c1418407-1418153 [Micrococcus luteus]
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCAAGCGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGACGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGCCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCAAGCGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGACGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGCCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9597.74 Da Isoelectric Point: 4.8359
>AT128990 WP_036340860.1 NZ_CP041689:c1418668-1418408 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA
Download Length: 261 bp
>AT128990 NZ_CP041689:c1418668-1418408 [Micrococcus luteus]
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTAGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTAGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y1LR91 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A229HG25 |