Detailed information of TA system TA128953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3214269..3214779
• Replicon: chromosome
• Accession: NZ_CP041660
• Organism: Catenovulum sediminis strain WS1-A

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FNT16_RS13730
• Protein ID: WP_143872104.1
• Coordinates: 3214516..3214779 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: W8G613
• Locus tag: FNT16_RS13725
• Protein ID: WP_015486388.1
• Coordinates: 3214269..3214523 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNT16_RS20400	3209393..3209554	-	162	WP_185976602.1	hypothetical protein	-
FNT16_RS13710	3209926..3210240	+	315	WP_143872102.1	hypothetical protein	-
FNT16_RS13715	3210884..3212179	+	1296	WP_185976603.1	group II intron reverse transcriptase/maturase	-
FNT16_RS13720	3212308..3212730	+	423	WP_143872103.1	hypothetical protein	-
FNT16_RS20405	3212916..3213077	-	162	WP_185976602.1	hypothetical protein	-
FNT16_RS13725	3214269..3214523	+	255	WP_015486388.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FNT16_RS13730	3214516..3214779	+	264	WP_143872104.1	Txe/YoeB family addiction module toxin	Toxin
FNT16_RS13735	3215410..3215643	+	234	WP_143872105.1	RNA-directed DNA polymerase (Reverse transcriptase)	-
FNT16_RS13740	3215772..3216041	-	270	WP_143872106.1	Txe/YoeB family addiction module toxin	-
FNT16_RS13745	3216022..3216294	-	273	WP_143872107.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FNT16_RS13750	3216639..3217445	-	807	Protein_2668	transposase	-
FNT16_RS13755	3217590..3218138	+	549	WP_143872108.1	hypothetical protein	-
FNT16_RS13765	3218470..3218955	+	486	WP_143872109.1	hypothetical protein	-
FNT16_RS13770	3218948..3219532	+	585	WP_143872110.1	putative adenosine monophosphate-protein transferase Fic	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10303.72 Da
• Isoelectric Point: 9.4332

>T128953 WP_143872104.1 NZ_CP041660:3214516-3214779 [Catenovulum sediminis]
MSSRLLCWTDEAWNDYVYWQGQGKKTLKRINKLISDTKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDKSLTI
ISCRYHY

Nucleotide

• Length: 264 bp

>T128953 NZ_CP041660:3214516-3214779 [Catenovulum sediminis]
ATGAGTAGTAGGCTACTTTGTTGGACTGATGAAGCTTGGAATGATTACGTTTACTGGCAAGGTCAGGGCAAAAAGACATT
AAAGCGTATAAACAAATTAATCAGTGACACTAAGCGTTCACCATTTGAGGGTATTGGCAAGCCTGAGCCTCTTAAAGAAA
ATTTGTCAGGTTTCTGGTCACGCCGTATTGATGACACCAATCGTTTAGTTTATGCCGTTGATGATAAAAGTCTAACCATA
ATATCGTGCAGGTATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9373.51 Da
• Isoelectric Point: 5.0481

>AT128953 WP_015486388.1 NZ_CP041660:3214269-3214523 [Catenovulum sediminis]
MRVVSFTEARNGLKAVLDSVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLKSPANAEHLNKSIAQYKSGKTTQRD
IVDE

Nucleotide

• Length: 255 bp

>AT128953 NZ_CP041660:3214269-3214523 [Catenovulum sediminis]
ATGAGAGTTGTATCTTTTACTGAAGCAAGAAATGGACTAAAAGCTGTTTTAGACTCTGTCGTTAATGATGCAGACACCAC
TGTTATCACGCGTCGAGATTCAGAAGATGCGGTAGTGATGTCATTAGATTATTACAATAGTTTGATGGAAACAGTTCATT
TGTTAAAGTCTCCTGCAAATGCAGAACATTTAAACAAATCAATAGCTCAATATAAAAGTGGTAAAACTACGCAAAGAGAT
ATAGTCGATGAGTAG

Structures

Antitoxin

• AlphaFold DB: W8G613