Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1492504..1493129 Replicon chromosome
Accession NZ_CP041644
Organism Klebsiella pneumoniae strain NKU_Kleb8A7

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag FOA47_RS07040 Protein ID WP_004187928.1
Coordinates 1492504..1492887 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag FOA47_RS07045 Protein ID WP_004150355.1
Coordinates 1492887..1493129 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOA47_RS07025 1489870..1490772 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
FOA47_RS07030 1490769..1491404 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
FOA47_RS07035 1491401..1492330 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
FOA47_RS07040 1492504..1492887 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
FOA47_RS07045 1492887..1493129 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
FOA47_RS07050 1493323..1494240 + 918 WP_004187929.1 alpha/beta hydrolase -
FOA47_RS07055 1494254..1495195 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
FOA47_RS07060 1495240..1495677 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
FOA47_RS07065 1495674..1496534 - 861 WP_004146232.1 virulence factor BrkB family protein -
FOA47_RS07070 1496528..1497127 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T128924 WP_004187928.1 NZ_CP041644:c1492887-1492504 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T128924 NZ_CP041644:c1492887-1492504 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT128924 WP_004150355.1 NZ_CP041644:c1493129-1492887 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT128924 NZ_CP041644:c1493129-1492887 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References