Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1003199..1003715 Replicon chromosome
Accession NZ_CP041644
Organism Klebsiella pneumoniae strain NKU_Kleb8A7

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag FOA47_RS04720 Protein ID WP_004192395.1
Coordinates 1003199..1003483 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag FOA47_RS04725 Protein ID WP_004192397.1
Coordinates 1003473..1003715 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOA47_RS04700 998616..998924 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
FOA47_RS27065 999009..999182 + 174 WP_002886906.1 hypothetical protein -
FOA47_RS04705 999185..999928 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FOA47_RS04710 1000285..1002423 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FOA47_RS04715 1002731..1003195 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FOA47_RS04720 1003199..1003483 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOA47_RS04725 1003473..1003715 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOA47_RS04730 1003793..1005703 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FOA47_RS04735 1005726..1006880 - 1155 WP_004178372.1 lactonase family protein -
FOA47_RS04740 1006947..1007687 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T128922 WP_004192395.1 NZ_CP041644:c1003483-1003199 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T128922 NZ_CP041644:c1003483-1003199 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT128922 WP_004192397.1 NZ_CP041644:c1003715-1003473 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT128922 NZ_CP041644:c1003715-1003473 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References