Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786314..786971 Replicon chromosome
Accession NZ_CP041639
Organism Klebsiella pneumoniae strain PIMB15ND2KP27

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DIJ67_RS03935 Protein ID WP_002916310.1
Coordinates 786561..786971 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DIJ67_RS03930 Protein ID WP_002916312.1
Coordinates 786314..786580 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DIJ67_RS03905 781470..782903 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DIJ67_RS03910 783022..783750 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DIJ67_RS03915 783800..784111 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DIJ67_RS03920 784275..784934 + 660 WP_002916317.1 hemolysin III family protein -
DIJ67_RS03925 785085..786068 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
DIJ67_RS03930 786314..786580 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DIJ67_RS03935 786561..786971 + 411 WP_002916310.1 protein YgfX Toxin
DIJ67_RS03940 786978..787499 - 522 WP_004144730.1 flavodoxin FldB -
DIJ67_RS03945 787600..788496 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DIJ67_RS03950 788519..789232 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DIJ67_RS03955 789238..790971 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T128900 WP_002916310.1 NZ_CP041639:786561-786971 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T128900 NZ_CP041639:786561-786971 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT128900 WP_002916312.1 NZ_CP041639:786314-786580 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT128900 NZ_CP041639:786314-786580 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References