Detailed information of TA system TA128886

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3562496..3563328
• Replicon: chromosome
• Accession: NZ_CP041628
• Organism: Escherichia coli strain PE15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0H2VCF5
• Locus tag: FNZ59_RS17290
• Protein ID: WP_000854681.1
• Coordinates: 3562496..3562873 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FNZ59_RS17295
• Protein ID: WP_088474659.1
• Coordinates: 3562963..3563328 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNZ59_RS17270	3558863..3560401	-	1539	WP_001187177.1	lysine decarboxylation/transport transcriptional activator CadC	-
FNZ59_RS17275	3561150..3561992	-	843	WP_001529559.1	DUF4942 domain-containing protein	-
FNZ59_RS17280	3562077..3562274	-	198	WP_023563519.1	DUF957 domain-containing protein	-
FNZ59_RS17285	3562350..3562499	-	150	Protein_3367	hypothetical protein	-
FNZ59_RS17290	3562496..3562873	-	378	WP_000854681.1	TA system toxin CbtA family protein	Toxin
FNZ59_RS17295	3562963..3563328	-	366	WP_088474659.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FNZ59_RS17300	3563406..3563627	-	222	WP_000692300.1	DUF987 domain-containing protein	-
FNZ59_RS17305	3563690..3564166	-	477	WP_001186171.1	RadC family protein	-
FNZ59_RS17310	3564181..3564666	-	486	WP_000206670.1	antirestriction protein	-
FNZ59_RS17315	3564758..3565576	-	819	WP_001175163.1	DUF945 domain-containing protein	-
FNZ59_RS17320	3565666..3565899	-	234	WP_073506913.1	DUF905 family protein	-
FNZ59_RS17325	3565905..3566582	-	678	WP_001097301.1	hypothetical protein	-
FNZ59_RS17330	3566730..3567410	-	681	WP_001282919.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3551374..3574587	23213

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (17-116)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13963.89 Da
• Isoelectric Point: 7.4348

>T128886 WP_000854681.1 NZ_CP041628:c3562873-3562496 [Escherichia coli]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T128886 NZ_CP041628:c3562873-3562496 [Escherichia coli]
ATGAAAACATTACCCGACACACACATACGGGAGGCATCGCACTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCAGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13554.36 Da
• Isoelectric Point: 6.2034

>AT128886 WP_088474659.1 NZ_CP041628:c3563328-3562963 [Escherichia coli]
VSDTLPGTTYPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 366 bp

>AT128886 NZ_CP041628:c3563328-3562963 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGTATCCCGACAACAACAACCGCCCCTGGTGGGGGCTACCCTGCACCGTGATGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAA
CTCAGCCCTCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCTTCGGCTCCTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACAAAAACGTAA

Structures

Toxin

• AlphaFold DB: A0A0H2VCF5