Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3551050..3551547 Replicon chromosome
Accession NZ_CP041628
Organism Escherichia coli strain PE15

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag FNZ59_RS17245 Protein ID WP_077492245.1
Coordinates 3551374..3551547 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag FNZ59_RS17240 Protein ID WP_000398619.1
Coordinates 3551050..3551346 (+) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ59_RS17220 3547781..3548500 - 720 WP_000611288.1 two-component system response regulator DcuR -
FNZ59_RS17225 3548497..3550128 - 1632 WP_001216477.1 sensor histidine kinase -
FNZ59_RS17230 3550309..3550539 + 231 WP_000371704.1 (4Fe-4S)-binding protein -
FNZ59_RS17235 3550551..3550823 + 273 WP_000405651.1 N-acetyltransferase -
FNZ59_RS17240 3551050..3551346 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
FNZ59_RS17245 3551374..3551547 + 174 WP_077492245.1 type V toxin-antitoxin system toxin GhoT Toxin
FNZ59_RS17250 3551666..3553183 - 1518 WP_001295074.1 lysine--tRNA ligase -
FNZ59_RS17255 3553420..3554877 - 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6631.16 Da        Isoelectric Point: 9.9031

>T128885 WP_077492245.1 NZ_CP041628:3551374-3551547 [Escherichia coli]
MALFYKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T128885 NZ_CP041628:3551374-3551547 [Escherichia coli]
ATGGCACTATTCTATAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT128885 WP_000398619.1 NZ_CP041628:3551050-3551346 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT128885 NZ_CP041628:3551050-3551346 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGACTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References