Detailed information of TA system TA128881

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2276880..2277715
• Replicon: chromosome
• Accession: NZ_CP041628
• Organism: Escherichia coli strain PE15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FNZ59_RS11195
• Protein ID: WP_160268073.1
• Coordinates: 2277338..2277715 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FNZ59_RS11190
• Protein ID: WP_024174331.1
• Coordinates: 2276880..2277248 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNZ59_RS11165	2274305..2274538	+	234	WP_001117568.1	DUF905 family protein	-
FNZ59_RS11170	2274629..2275447	+	819	WP_106464784.1	DUF945 domain-containing protein	-
FNZ59_RS11175	2275539..2276024	+	486	WP_106464783.1	antirestriction protein	-
FNZ59_RS11180	2276040..2276516	+	477	WP_001186771.1	RadC family protein	-
FNZ59_RS11185	2276585..2276806	+	222	WP_000692346.1	DUF987 domain-containing protein	-
FNZ59_RS11190	2276880..2277248	+	369	WP_024174331.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FNZ59_RS11195	2277338..2277715	+	378	WP_160268073.1	TA system toxin CbtA family protein	Toxin
FNZ59_RS11200	2277712..2278200	+	489	WP_000761718.1	hypothetical protein	-
FNZ59_RS11205	2278212..2278409	+	198	WP_000838536.1	DUF957 domain-containing protein	-
FNZ59_RS11210	2278494..2279336	+	843	WP_113446799.1	DUF4942 domain-containing protein	-
FNZ59_RS11215	2279617..2280153	-	537	WP_077492888.1	GspM family type II secretion system protein YghD	-
FNZ59_RS11220	2280155..2280808	-	654	Protein_2198	type II secretion system protein GspL	-
FNZ59_RS11225	2280786..2281430	-	645	Protein_2199	type II secretion system protein GspC	-
FNZ59_RS11230	2281448..2281858	-	411	WP_001300497.1	type II secretion system pilot lipoprotein GspS-beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14175.06 Da
• Isoelectric Point: 6.6306

>T128881 WP_160268073.1 NZ_CP041628:2277338-2277715 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRAHRATGLMTRDNYRMVNNITQGKHPEAQQ

Nucleotide

• Length: 378 bp

>T128881 NZ_CP041628:2277338-2277715 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCACCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13603.42 Da
• Isoelectric Point: 6.7386

>AT128881 WP_024174331.1 NZ_CP041628:2276880-2277248 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 369 bp

>AT128881 NZ_CP041628:2276880-2277248 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA