Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3167965..3168625 Replicon chromosome
Accession NZ_CP041627
Organism Escherichia coli strain ETEC6

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag FNW97_RS15935 Protein ID WP_029701967.1
Coordinates 3167965..3168378 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FNW97_RS15940 Protein ID WP_000354046.1
Coordinates 3168359..3168625 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW97_RS15915 3163929..3165662 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
FNW97_RS15920 3165668..3166378 - 711 WP_000715231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FNW97_RS15925 3166402..3167298 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FNW97_RS15930 3167410..3167931 + 522 WP_001055874.1 flavodoxin FldB -
FNW97_RS15935 3167965..3168378 - 414 WP_029701967.1 protein YgfX Toxin
FNW97_RS15940 3168359..3168625 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FNW97_RS15945 3168868..3169848 + 981 WP_000886083.1 tRNA-modifying protein YgfZ -
FNW97_RS15950 3169925..3170584 - 660 WP_047603410.1 hemolysin III family protein -
FNW97_RS15955 3170748..3171059 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
FNW97_RS15960 3171104..3172537 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
FNW97_RS15965 3172594..3173337 - 744 WP_047603407.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T128856 WP_029701967.1 NZ_CP041627:c3168378-3167965 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T128856 NZ_CP041627:c3168378-3167965 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGCTTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT128856 WP_000354046.1 NZ_CP041627:c3168625-3168359 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT128856 NZ_CP041627:c3168625-3168359 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAATTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References