Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1538048..1538686 Replicon chromosome
Accession NZ_CP041627
Organism Escherichia coli strain ETEC6

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag FNW97_RS07655 Protein ID WP_000813794.1
Coordinates 1538048..1538224 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FNW97_RS07660 Protein ID WP_001270286.1
Coordinates 1538270..1538686 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW97_RS07635 1533667..1534881 - 1215 WP_071597387.1 BenE family transporter YdcO -
FNW97_RS07640 1534934..1535470 + 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
FNW97_RS07645 1535543..1537504 + 1962 WP_047603723.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FNW97_RS07650 1537596..1537826 - 231 WP_000494244.1 YncJ family protein -
FNW97_RS07655 1538048..1538224 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FNW97_RS07660 1538270..1538686 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FNW97_RS07665 1538765..1540171 + 1407 WP_047603724.1 PLP-dependent aminotransferase family protein -
FNW97_RS07670 1540416..1541561 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
FNW97_RS07675 1541579..1542592 + 1014 WP_149796516.1 ABC transporter ATP-binding protein -
FNW97_RS07680 1542593..1543534 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1532362..1533627 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T128845 WP_000813794.1 NZ_CP041627:1538048-1538224 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T128845 NZ_CP041627:1538048-1538224 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT128845 WP_001270286.1 NZ_CP041627:1538270-1538686 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT128845 NZ_CP041627:1538270-1538686 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References