Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 460381..460999 Replicon chromosome
Accession NZ_CP041627
Organism Escherichia coli strain ETEC6

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FNW97_RS02190 Protein ID WP_001291435.1
Coordinates 460381..460599 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FNW97_RS02195 Protein ID WP_000344800.1
Coordinates 460625..460999 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW97_RS02155 455670..456242 + 573 WP_047603642.1 YbaY family lipoprotein -
FNW97_RS02160 456273..456584 - 312 WP_000409911.1 MGMT family protein -
FNW97_RS02170 456963..457316 + 354 WP_000878140.1 DUF1428 domain-containing protein -
FNW97_RS02175 457358..458908 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FNW97_RS02180 459072..459542 - 471 WP_000136192.1 YlaC family protein -
FNW97_RS02185 459658..460209 - 552 WP_000102564.1 maltose O-acetyltransferase -
FNW97_RS02190 460381..460599 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FNW97_RS02195 460625..460999 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FNW97_RS02200 461545..464694 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
FNW97_RS02205 464717..465910 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T128844 WP_001291435.1 NZ_CP041627:c460599-460381 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T128844 NZ_CP041627:c460599-460381 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT128844 WP_000344800.1 NZ_CP041627:c460999-460625 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT128844 NZ_CP041627:c460999-460625 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References