Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 851111..851601 Replicon chromosome
Accession NZ_CP041626
Organism Dolosigranulum pigrum strain 83VPs-KB5

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FNV33_RS04030 Protein ID WP_004636454.1
Coordinates 851335..851601 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FNV33_RS04025 Protein ID WP_004636455.1
Coordinates 851111..851338 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNV33_RS04015 846294..848147 + 1854 WP_143333326.1 oligopeptide ABC transporter substrate-binding protein -
FNV33_RS04020 848224..850776 - 2553 WP_143333327.1 penicillin-binding protein -
FNV33_RS04025 851111..851338 + 228 WP_004636455.1 hypothetical protein Antitoxin
FNV33_RS04030 851335..851601 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNV33_RS04035 851713..852678 - 966 WP_143333328.1 rhodanese-related sulfurtransferase -
FNV33_RS04040 852814..854619 - 1806 WP_143333329.1 M3 family oligoendopeptidase -
FNV33_RS04045 854774..855241 - 468 WP_143333330.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T128841 WP_004636454.1 NZ_CP041626:851335-851601 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T128841 NZ_CP041626:851335-851601 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT128841 WP_004636455.1 NZ_CP041626:851111-851338 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT128841 NZ_CP041626:851111-851338 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References