Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4526229..4526707 Replicon chromosome
Accession NZ_CP041623
Organism Escherichia coli O157:H7 strain ATCC 43888

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FNZ21_RS22985 Protein ID WP_001303876.1
Coordinates 4526420..4526707 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FNZ21_RS22980 Protein ID WP_000536233.1
Coordinates 4526229..4526420 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ21_RS22945 4521633..4522403 - 771 WP_000450992.1 DUF1627 domain-containing protein -
FNZ21_RS22950 4522425..4523171 - 747 WP_000788751.1 ATP-binding protein -
FNZ21_RS22955 4523178..4524269 - 1092 WP_001205823.1 hypothetical protein -
FNZ21_RS22960 4524348..4524803 + 456 WP_000273724.1 hypothetical protein -
FNZ21_RS22965 4525010..4525435 - 426 WP_000693855.1 Rha family transcriptional regulator -
FNZ21_RS22970 4525419..4525691 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FNZ21_RS22975 4525800..4526201 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FNZ21_RS22980 4526229..4526420 + 192 WP_000536233.1 hypothetical protein Antitoxin
FNZ21_RS22985 4526420..4526707 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNZ21_RS22995 4526985..4527140 + 156 WP_000379575.1 DUF1391 family protein -
FNZ21_RS23000 4527282..4527671 + 390 WP_000394511.1 hypothetical protein -
FNZ21_RS23005 4527858..4528043 - 186 WP_001133046.1 hypothetical protein -
FNZ21_RS23015 4528617..4528805 + 189 WP_000413705.1 cell division inhibition protein DicB -
FNZ21_RS23020 4528802..4528993 + 192 WP_001098307.1 DUF1482 family protein -
FNZ21_RS23025 4529087..4531558 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T128833 WP_001303876.1 NZ_CP041623:4526420-4526707 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T128833 NZ_CP041623:4526420-4526707 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT128833 WP_000536233.1 NZ_CP041623:4526229-4526420 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT128833 NZ_CP041623:4526229-4526420 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References