Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 460465..461300 | Replicon | chromosome |
| Accession | NZ_CP041623 | ||
| Organism | Escherichia coli O157:H7 strain ATCC 43888 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B1LDL9 |
| Locus tag | FNZ21_RS02090 | Protein ID | WP_001094444.1 |
| Coordinates | 460465..460842 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7LDN9 |
| Locus tag | FNZ21_RS02095 | Protein ID | WP_001285607.1 |
| Coordinates | 460932..461300 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNZ21_RS02055 | 456614..456856 | + | 243 | Protein_400 | N-acetylneuraminic acid mutarotase | - |
| FNZ21_RS02060 | 456930..457781 | + | 852 | WP_000168589.1 | HNH endonuclease | - |
| FNZ21_RS02065 | 457979..458166 | - | 188 | Protein_402 | transposase | - |
| FNZ21_RS02070 | 458241..459068 | - | 828 | WP_001301682.1 | integrase arm-type DNA-binding domain-containing protein | - |
| FNZ21_RS27795 | 459532..459678 | - | 147 | WP_001290178.1 | hypothetical protein | - |
| FNZ21_RS02080 | 459763..459960 | - | 198 | WP_001327226.1 | DUF957 domain-containing protein | - |
| FNZ21_RS02085 | 459980..460468 | - | 489 | WP_000761685.1 | hypothetical protein | - |
| FNZ21_RS02090 | 460465..460842 | - | 378 | WP_001094444.1 | TA system toxin CbtA family protein | Toxin |
| FNZ21_RS02095 | 460932..461300 | - | 369 | WP_001285607.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FNZ21_RS02100 | 461380..461601 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| FNZ21_RS02105 | 461688..462164 | - | 477 | WP_001186780.1 | RadC family protein | - |
| FNZ21_RS02110 | 462180..462665 | - | 486 | WP_000213716.1 | antirestriction protein | - |
| FNZ21_RS02115 | 462757..463575 | - | 819 | WP_001175175.1 | DUF945 domain-containing protein | - |
| FNZ21_RS02120 | 463665..463874 | - | 210 | WP_032150870.1 | DUF905 family protein | - |
| FNZ21_RS02125 | 463904..464581 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| FNZ21_RS02130 | 464729..465409 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 452916..498199 | 45283 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14087.02 Da Isoelectric Point: 7.3523
>T128809 WP_001094444.1 NZ_CP041623:c460842-460465 [Escherichia coli O157:H7]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T128809 NZ_CP041623:c460842-460465 [Escherichia coli O157:H7]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13689.53 Da Isoelectric Point: 6.4669
>AT128809 WP_001285607.1 NZ_CP041623:c461300-460932 [Escherichia coli O157:H7]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT128809 NZ_CP041623:c461300-460932 [Escherichia coli O157:H7]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B1LDL9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0JLU8 |