Detailed information of TA system TA128790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2193841..2194655
• Replicon: chromosome
• Accession: NZ_CP041620
• Organism: Shigella flexneri strain C32

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: FNL95_RS11765
• Protein ID: WP_001054376.1
• Coordinates: 2193841..2194098 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: S1NWL7
• Locus tag: FNL95_RS11770
• Protein ID: WP_001540600.1
• Coordinates: 2194110..2194655 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNL95_RS11745	2189129..2190235	+	1107	WP_001774143.1	N-acetylneuraminate epimerase	-
FNL95_RS11750	2190300..2191280	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
FNL95_RS11755	2191863..2192849	-	987	WP_001323209.1	hypothetical protein	-
FNL95_RS11760	2193219..2193464	+	246	Protein_2129	GNAT family N-acetyltransferase	-
FNL95_RS11765	2193841..2194098	+	258	WP_001054376.1	hypothetical protein	Toxin
FNL95_RS11770	2194110..2194655	+	546	WP_001540600.1	N-acetyltransferase	Antitoxin
FNL95_RS11775	2194711..2195457	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
FNL95_RS11780	2195626..2195844	+	219	Protein_2133	hypothetical protein	-
FNL95_RS11785	2196243..2197364	+	1122	WP_000010829.1	M42 family metallopeptidase	-
FNL95_RS11790	2197361..2197639	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
FNL95_RS11795	2197651..2198963	+	1313	Protein_2136	permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	2183228..2202878	19650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T128790 WP_001054376.1 NZ_CP041620:2193841-2194098 [Shigella flexneri]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T128790 NZ_CP041620:2193841-2194098 [Shigella flexneri]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19926.87 Da
• Isoelectric Point: 6.3277

>AT128790 WP_001540600.1 NZ_CP041620:2194110-2194655 [Shigella flexneri]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT128790 NZ_CP041620:2194110-2194655 [Shigella flexneri]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: S1NWL7