Detailed information of TA system TA128768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3368248..3368912
• Replicon: chromosome
• Accession: NZ_CP041616
• Organism: Ornithinimicrobium sp. H23M54

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FNH13_RS15585
• Protein ID: WP_143784283.1
• Coordinates: 3368248..3368676 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FNH13_RS15590
• Protein ID: WP_143784284.1
• Coordinates: 3368673..3368912 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNH13_RS15560	3363337..3363618	+	282	WP_143784277.1	hypothetical protein	-
FNH13_RS15565	3363615..3364007	+	393	WP_165700149.1	type II toxin-antitoxin system VapC family toxin	-
FNH13_RS15570	3364083..3365393	-	1311	WP_143784280.1	AarF/ABC1/UbiB kinase family protein	-
FNH13_RS15575	3365631..3366671	+	1041	WP_143784281.1	hypothetical protein	-
FNH13_RS15580	3366922..3368127	+	1206	WP_143784282.1	amidohydrolase family protein	-
FNH13_RS15585	3368248..3368676	-	429	WP_143784283.1	type II toxin-antitoxin system VapC family toxin	Toxin
FNH13_RS15590	3368673..3368912	-	240	WP_143784284.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FNH13_RS15595	3369363..3370445	+	1083	WP_143784285.1	GNAT family N-acetyltransferase	-
FNH13_RS15600	3370584..3371660	+	1077	WP_202878806.1	Fic family protein	-
FNH13_RS19350	3371678..3372226	+	549	WP_202878807.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-125)

Antitoxin

• SpoVT-AbrB domain (3-42)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 14944.80 Da
• Isoelectric Point: 5.5218

>T128768 WP_143784283.1 NZ_CP041616:c3368676-3368248 [Ornithinimicrobium sp. H23M54]
VSSEPQVVLDTSAAVPLLVSSHEAHAMVSSWAVGRVLGLSGHALAETYAVLTRLPGDSRVSPADAVRLIDDNFQYRLVLD
SEVAGDAHRELARCGVSGGATYDGLVALTARAHDAVLVTRDARARPTYEAVGAQVQVLVDTR

Nucleotide

• Length: 429 bp

>T128768 NZ_CP041616:c3368676-3368248 [Ornithinimicrobium sp. H23M54]
GTGAGCAGCGAGCCGCAGGTGGTGCTCGACACGAGCGCGGCCGTGCCGTTGCTTGTGTCGTCGCACGAGGCGCACGCCAT
GGTCTCCTCCTGGGCGGTCGGGCGAGTGCTCGGTCTCAGCGGTCATGCTCTTGCCGAGACCTATGCGGTCCTGACCCGGC
TGCCCGGCGACTCTCGGGTGAGTCCCGCCGACGCGGTGCGGCTGATTGATGACAACTTCCAGTACCGACTGGTGCTCGAC
TCCGAAGTGGCGGGAGATGCTCATCGAGAGTTGGCGCGTTGCGGGGTGTCGGGCGGAGCGACCTACGACGGACTGGTCGC
CCTGACCGCCCGGGCACACGACGCGGTTCTCGTCACCCGAGACGCCCGGGCCAGGCCCACCTACGAAGCGGTGGGTGCGC
AGGTGCAGGTGCTCGTCGACACGCGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8304.40 Da
• Isoelectric Point: 8.7161

>AT128768 WP_143784284.1 NZ_CP041616:c3368912-3368673 [Ornithinimicrobium sp. H23M54]
MKATIDSGGRLLLPKSLRDALGLGPGSTVDVSRYGSGVQITPGGRTARLERTEDGRLVATSETVVTDDVMFGLIDSGRR

Nucleotide

• Length: 240 bp

>AT128768 NZ_CP041616:c3368912-3368673 [Ornithinimicrobium sp. H23M54]
ATGAAGGCGACGATTGACTCGGGCGGACGGCTCCTGCTGCCGAAGAGCCTGCGGGACGCATTGGGCCTCGGCCCCGGTTC
GACGGTGGATGTGTCGCGTTACGGCAGTGGAGTCCAGATCACACCGGGGGGTCGCACGGCTCGGTTGGAGCGGACCGAGG
ACGGTCGCTTGGTGGCAACGTCTGAGACTGTCGTCACCGACGACGTGATGTTCGGGTTGATCGACTCGGGCCGGCGGTGA