Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3356781..3357391 Replicon chromosome
Accession NZ_CP041616
Organism Ornithinimicrobium sp. H23M54

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNH13_RS15520 Protein ID WP_165700148.1
Coordinates 3356987..3357391 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FNH13_RS15515 Protein ID WP_165700147.1
Coordinates 3356781..3356990 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNH13_RS15490 3352736..3354103 + 1368 WP_143784260.1 aspartate aminotransferase family protein -
FNH13_RS15495 3354210..3354602 + 393 WP_143784262.1 hypothetical protein -
FNH13_RS15500 3354679..3354990 + 312 WP_202878983.1 hypothetical protein -
FNH13_RS15505 3354987..3356231 + 1245 WP_143784265.1 sigma-70 family RNA polymerase sigma factor -
FNH13_RS19140 3356298..3356453 + 156 WP_165699940.1 hypothetical protein -
FNH13_RS15510 3356416..3356703 + 288 WP_143784266.1 hypothetical protein -
FNH13_RS15515 3356781..3356990 + 210 WP_165700147.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FNH13_RS15520 3356987..3357391 + 405 WP_165700148.1 PIN domain nuclease Toxin
FNH13_RS15525 3357473..3358132 - 660 WP_143784268.1 hypothetical protein -
FNH13_RS15530 3358290..3359921 + 1632 WP_143784270.1 sensor histidine kinase -
FNH13_RS15535 3359918..3360580 + 663 WP_143784271.1 response regulator transcription factor -
FNH13_RS15540 3360755..3361087 + 333 WP_143784272.1 hypothetical protein -
FNH13_RS15545 3361065..3361421 + 357 WP_143784273.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-41)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15054.32 Da        Isoelectric Point: 5.0125

>T128767 WP_165700148.1 NZ_CP041616:3356987-3357391 [Ornithinimicrobium sp. H23M54]
VIVDTSVWIEFLRPGPSKAGDHLESLIRQQERLVVPETVLMELLSGTADEVAADRRLRMLESFEVTPTEPVVDSLAAARL
QRACRREGESVRNLGDCLIASVSLRLDVPVLHRDRDFEVLRRHCGIQTVSLLEL

Download         Length: 405 bp

>T128767 NZ_CP041616:3356987-3357391 [Ornithinimicrobium sp. H23M54]
GTGATCGTCGACACCTCGGTGTGGATCGAGTTCCTGCGACCCGGTCCCTCCAAGGCTGGTGACCATCTTGAGTCCCTGAT
CCGGCAGCAGGAACGGCTCGTGGTCCCCGAGACCGTGCTGATGGAGTTGCTGAGTGGCACGGCTGATGAGGTCGCTGCTG
ATCGTCGCCTCCGGATGCTCGAGTCCTTCGAGGTGACACCCACCGAACCCGTTGTTGACTCACTGGCTGCGGCGCGCCTC
CAGCGTGCGTGCCGCCGCGAAGGCGAGTCCGTCCGCAACCTCGGCGACTGCCTCATTGCCAGCGTTTCCCTGCGCCTGGA
TGTGCCTGTGCTTCACCGGGACCGGGACTTCGAGGTGCTCCGCCGACACTGCGGCATTCAGACCGTGTCCCTCCTCGAGC
TCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7843.84 Da        Isoelectric Point: 4.0941

>AT128767 WP_165700147.1 NZ_CP041616:3356781-3356990 [Ornithinimicrobium sp. H23M54]
MARTNIDLDDELVTSVMARYRLESKRAAVDFALRQLIREPLTLDEILAMRGSGFEVDNEEIEGDWAVST

Download         Length: 210 bp

>AT128767 NZ_CP041616:3356781-3356990 [Ornithinimicrobium sp. H23M54]
ATGGCACGGACCAACATCGACCTTGACGACGAGCTGGTCACGTCAGTGATGGCGCGCTATCGGCTTGAGTCCAAGCGCGC
CGCAGTCGACTTCGCCCTCCGGCAGCTGATTCGCGAGCCTCTGACCCTGGACGAGATCCTTGCCATGAGGGGCAGCGGGT
TCGAGGTCGACAACGAGGAGATCGAGGGAGACTGGGCGGTCTCCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References