Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3221375..3221894 Replicon chromosome
Accession NZ_CP041616
Organism Ornithinimicrobium sp. H23M54

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FNH13_RS14910 Protein ID WP_143784148.1
Coordinates 3221375..3221632 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FNH13_RS14915 Protein ID WP_143784149.1
Coordinates 3221637..3221894 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNH13_RS14875 3217066..3217551 + 486 WP_143784142.1 helix-turn-helix domain-containing protein -
FNH13_RS14880 3217551..3218123 + 573 WP_143785163.1 hypothetical protein -
FNH13_RS14885 3218384..3218833 - 450 WP_143784143.1 hypothetical protein -
FNH13_RS14890 3219122..3219319 + 198 WP_143784144.1 ribbon-helix-helix protein, CopG family -
FNH13_RS14895 3219316..3219705 + 390 WP_143784145.1 type II toxin-antitoxin system death-on-curing family toxin -
FNH13_RS14900 3220004..3220225 + 222 WP_143784146.1 DUF86 domain-containing protein -
FNH13_RS14905 3220576..3221202 - 627 WP_143784147.1 YceI family protein -
FNH13_RS14910 3221375..3221632 - 258 WP_143784148.1 Txe/YoeB family addiction module toxin Toxin
FNH13_RS14915 3221637..3221894 - 258 WP_143784149.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FNH13_RS14920 3222063..3223220 - 1158 WP_202878794.1 DUF3322 and DUF2220 domain-containing protein -
FNH13_RS14925 3223256..3226678 - 3423 WP_143784151.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10040.38 Da        Isoelectric Point: 6.7090

>T128766 WP_143784148.1 NZ_CP041616:c3221632-3221375 [Ornithinimicrobium sp. H23M54]
VLLVWDENAWEDCLWWQAQDRTVLKRINLLLKDIQRNGNEGIGKPEALEHDFAGYWSRRITDEHRLVYKIAGAEVRVAAC
RYHYG

Download         Length: 258 bp

>T128766 NZ_CP041616:c3221632-3221375 [Ornithinimicrobium sp. H23M54]
GTGCTGCTGGTCTGGGACGAGAACGCCTGGGAGGACTGCCTTTGGTGGCAGGCGCAGGACCGCACAGTGCTCAAACGCAT
CAACCTGCTCCTGAAGGACATCCAACGCAACGGCAACGAGGGGATCGGCAAGCCTGAGGCGCTGGAACACGACTTTGCCG
GCTACTGGTCGCGCCGCATCACCGACGAGCATCGGCTCGTGTACAAGATCGCTGGGGCCGAGGTCCGAGTCGCCGCCTGC
CGCTACCACTACGGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9674.88 Da        Isoelectric Point: 4.8951

>AT128766 WP_143784149.1 NZ_CP041616:c3221894-3221637 [Ornithinimicrobium sp. H23M54]
MKTMSYTESRARYAEVLDGVTNDREEVVITRAGHEPVVIVSLADYESLRETAYLMRSPANARRLLDAMERLEAGRGRSRE
LVETD

Download         Length: 258 bp

>AT128766 NZ_CP041616:c3221894-3221637 [Ornithinimicrobium sp. H23M54]
ATGAAGACTATGAGTTACACCGAGTCGCGAGCACGTTACGCAGAAGTGCTGGACGGCGTCACCAACGACCGTGAAGAGGT
CGTCATCACGCGCGCCGGCCACGAGCCGGTCGTCATCGTCTCTCTGGCGGACTACGAGTCGCTACGTGAGACGGCCTACC
TCATGCGCTCACCCGCCAACGCCCGTCGGCTGCTGGACGCCATGGAGCGGCTGGAGGCTGGCCGGGGGCGGTCGCGCGAG
CTGGTCGAGACGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References