Detailed information of TA system TA128765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 1428738..1429390
• Replicon: chromosome
• Accession: NZ_CP041616
• Organism: Ornithinimicrobium sp. H23M54

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FNH13_RS06625
• Protein ID: WP_165700039.1
• Coordinates: 1428995..1429390 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FNH13_RS06620
• Protein ID: WP_202878880.1
• Coordinates: 1428738..1428998 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNH13_RS06610	1425471..1427684	+	2214	WP_143782736.1	methylmalonyl-CoA mutase	-
FNH13_RS06615	1427674..1428651	+	978	WP_143782737.1	methylmalonyl Co-A mutase-associated GTPase MeaB	-
FNH13_RS06620	1428738..1428998	+	261	WP_202878880.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FNH13_RS06625	1428995..1429390	+	396	WP_165700039.1	PIN domain-containing protein	Toxin
FNH13_RS06630	1429465..1429893	-	429	WP_143782738.1	type II toxin-antitoxin system VapC family toxin	-
FNH13_RS06635	1429890..1430129	-	240	WP_143782739.1	CopG family transcriptional regulator	-
FNH13_RS06640	1430403..1433300	+	2898	WP_143782740.1	leucine--tRNA ligase	-
FNH13_RS06645	1433357..1434226	+	870	WP_143782741.1	DegV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-55)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14249.35 Da
• Isoelectric Point: 4.7079

>T128765 WP_165700039.1 NZ_CP041616:1428995-1429390 [Ornithinimicrobium sp. H23M54]
MTEGLADTSVWISAEVGRRLDRARLPDVLRVSVITLAELQAGVLAASDPVSVSTRLRTLQLAQESEPLPVDAAVGQEWAL
LRVEVARAGKRLNVNDLWIAATARANRLPVVTQDDDFEVLATRGLIDLVRV

Nucleotide

• Length: 396 bp

>T128765 NZ_CP041616:1428995-1429390 [Ornithinimicrobium sp. H23M54]
ATGACTGAAGGGTTGGCGGACACCAGCGTTTGGATCTCCGCCGAGGTGGGCCGGCGGCTTGATCGGGCCAGGCTCCCGGA
TGTGTTGCGCGTCAGCGTCATCACCCTGGCGGAACTCCAGGCTGGGGTCCTGGCAGCCTCCGATCCAGTGAGCGTCTCCA
CGCGGCTGCGGACCCTCCAGCTGGCACAAGAGAGCGAGCCCCTCCCGGTTGACGCGGCCGTCGGGCAGGAGTGGGCACTC
TTGCGAGTCGAGGTCGCTCGAGCGGGCAAGCGCCTCAATGTCAACGACCTCTGGATCGCAGCCACTGCCCGTGCCAACAG
GTTGCCTGTTGTCACTCAGGACGATGACTTTGAGGTGCTCGCCACACGTGGCCTGATCGACCTCGTCCGGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9207.38 Da
• Isoelectric Point: 6.4780

>AT128765 WP_202878880.1 NZ_CP041616:1428738-1428998 [Ornithinimicrobium sp. H23M54]
VTTIASRDLRNHTAAVLKQVADGVEVTVTVHGEPAALITRPRHQRRTGLPKAELLAHLDRQQPDPTLADDIAWISAGSTD
ELGPLG

Nucleotide

• Length: 261 bp

>AT128765 NZ_CP041616:1428738-1428998 [Ornithinimicrobium sp. H23M54]
GTGACGACCATTGCTTCCCGCGATCTCCGGAACCACACTGCCGCCGTGCTCAAACAGGTGGCTGATGGTGTGGAGGTCAC
TGTCACTGTCCACGGTGAGCCGGCGGCCCTCATCACCCGGCCGCGACACCAGCGACGCACTGGTCTGCCCAAGGCTGAAC
TCCTGGCTCACCTGGACCGTCAGCAGCCAGATCCCACGCTCGCCGACGACATCGCCTGGATCTCCGCGGGTTCGACCGAC
GAGCTTGGTCCGCTCGGATGA