Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 697440..698107 Replicon chromosome
Accession NZ_CP041616
Organism Ornithinimicrobium sp. H23M54

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNH13_RS03140 Protein ID WP_143782111.1
Coordinates 697712..698107 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FNH13_RS03135 Protein ID WP_143782110.1
Coordinates 697440..697715 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNH13_RS03120 693392..694516 + 1125 WP_202878923.1 energy-coupling factor transporter transmembrane protein EcfT -
FNH13_RS03125 694513..696297 + 1785 WP_143782108.1 ABC transporter ATP-binding protein -
FNH13_RS19190 696292..696474 - 183 WP_202878856.1 hypothetical protein -
FNH13_RS03130 696519..697343 + 825 WP_202878924.1 ECF transporter S component -
FNH13_RS03135 697440..697715 + 276 WP_143782110.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FNH13_RS03140 697712..698107 + 396 WP_143782111.1 type II toxin-antitoxin system VapC family toxin Toxin
FNH13_RS03145 698094..698966 - 873 WP_143782112.1 alpha/beta hydrolase -
FNH13_RS03150 699050..699544 + 495 WP_143782113.1 sigma-70 family RNA polymerase sigma factor -
FNH13_RS03155 699537..700631 + 1095 WP_143782114.1 hypothetical protein -
FNH13_RS03160 700679..701875 + 1197 WP_143782115.1 L-2-hydroxyglutarate oxidase -
FNH13_RS03165 701872..702399 + 528 WP_165700004.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-38)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14017.05 Da        Isoelectric Point: 5.5335

>T128764 WP_143782111.1 NZ_CP041616:697712-698107 [Ornithinimicrobium sp. H23M54]
VSALYVDSSALCKLVAEEEHTAAMHRLWTTHDGDLVSSDLARTEVMRQAGRCDPPRGSEARAVLDALVLVPLLTRITQGA
GTLGPPSLRSLAALHLMTALELGDDLVGVVTYDERQAEAARHLGLPVITPR

Download         Length: 396 bp

>T128764 NZ_CP041616:697712-698107 [Ornithinimicrobium sp. H23M54]
GTGAGCGCGCTCTATGTCGACTCCTCCGCCTTGTGCAAGCTGGTGGCCGAGGAGGAGCACACGGCGGCCATGCACCGGTT
GTGGACGACCCACGACGGTGACCTCGTATCCAGTGACCTGGCCCGCACCGAGGTGATGCGTCAGGCCGGACGGTGTGATC
CGCCACGCGGGAGCGAGGCCCGGGCCGTGCTGGATGCCCTGGTGCTGGTGCCCCTCCTGACCCGGATCACCCAGGGTGCA
GGGACACTCGGGCCACCCTCCCTGCGCAGCCTGGCCGCGCTGCACCTGATGACGGCCCTGGAGCTGGGTGACGATCTGGT
GGGGGTCGTGACCTACGACGAGCGGCAGGCCGAGGCGGCGCGACACCTTGGGTTGCCGGTGATCACGCCCCGCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9649.87 Da        Isoelectric Point: 6.3228

>AT128764 WP_143782110.1 NZ_CP041616:697440-697715 [Ornithinimicrobium sp. H23M54]
MSTVGIRELRQSASAVVARAAAGETITITDRGRPVAQIGPRTPNGLQALREQGLVREPRASAADVPLPAPLPDDAPSLSQ
SLEADREERLR

Download         Length: 276 bp

>AT128764 NZ_CP041616:697440-697715 [Ornithinimicrobium sp. H23M54]
ATGAGCACGGTGGGAATCAGAGAGCTCCGGCAGAGCGCGTCTGCCGTCGTCGCACGGGCAGCCGCGGGGGAGACGATCAC
GATCACGGACCGGGGGCGGCCGGTGGCCCAGATCGGACCACGCACGCCCAACGGGTTGCAGGCGCTGCGCGAGCAGGGGC
TGGTGCGGGAGCCGCGAGCGTCGGCGGCGGACGTGCCCCTGCCCGCGCCACTCCCCGACGATGCACCGAGCCTGAGTCAG
TCGCTGGAGGCTGACCGCGAGGAGCGGTTGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References