Detailed information of TA system TA128763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 661618..662237
• Replicon: chromosome
• Accession: NZ_CP041616
• Organism: Ornithinimicrobium sp. H23M54

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FNH13_RS02975
• Protein ID: WP_143782082.1
• Coordinates: 661845..662237 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FNH13_RS02970
• Protein ID: WP_143782081.1
• Coordinates: 661618..661848 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNH13_RS02950	657078..659027	-	1950	WP_143784912.1	glycosyltransferase	-
FNH13_RS02955	659115..660218	-	1104	WP_143782078.1	acyltransferase	-
FNH13_RS02960	660279..660911	-	633	WP_143782079.1	TIGR03085 family protein	-
FNH13_RS02965	660916..661485	-	570	WP_143782080.1	peptide deformylase	-
FNH13_RS02970	661618..661848	+	231	WP_143782081.1	hypothetical protein	Antitoxin
FNH13_RS02975	661845..662237	+	393	WP_143782082.1	PIN domain-containing protein	Toxin
FNH13_RS02980	662253..662963	-	711	WP_143782083.1	PH domain-containing protein	-
FNH13_RS18940	663002..663169	-	168	WP_165699996.1	hypothetical protein	-
FNH13_RS02985	663296..664411	-	1116	WP_165699997.1	glycosyltransferase family 4 protein	-
FNH13_RS02990	664552..665571	+	1020	WP_143784913.1	glycosyltransferase family 4 protein	-
FNH13_RS02995	665582..666367	-	786	WP_143782085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14428.46 Da
• Isoelectric Point: 6.2816

>T128763 WP_143782082.1 NZ_CP041616:661845-662237 [Ornithinimicrobium sp. H23M54]
MSHYLLDANVLIALTVVEHEHHERAATWLPTVDRFAVCPVVEGALVRFLVRIGESTRTASEILSGVWAHPRCEFWPDDLS
YRDVDLTVVRGHRQVTDTYLVGLARGHDGMLATFDSALVAAHPRSSVLIG

Nucleotide

• Length: 393 bp

>T128763 NZ_CP041616:661845-662237 [Ornithinimicrobium sp. H23M54]
ATGAGCCACTACTTGCTCGATGCCAATGTGCTGATCGCCCTGACCGTCGTTGAGCATGAGCACCACGAGCGGGCCGCAAC
GTGGCTGCCGACCGTTGACCGTTTCGCGGTGTGTCCGGTCGTGGAGGGCGCCCTGGTCCGGTTCCTCGTTCGCATCGGAG
AGTCCACTCGGACGGCCAGCGAGATTCTGAGCGGTGTGTGGGCCCACCCGCGGTGCGAGTTCTGGCCCGACGACCTGTCC
TACCGAGACGTGGATCTCACTGTCGTGCGGGGTCATCGGCAGGTCACCGACACCTATCTCGTCGGGCTCGCCCGTGGGCA
CGACGGCATGCTGGCCACGTTCGACAGCGCCCTCGTGGCTGCACACCCCCGCTCAAGCGTGCTCATCGGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8085.16 Da
• Isoelectric Point: 4.3297

>AT128763 WP_143782081.1 NZ_CP041616:661618-661848 [Ornithinimicrobium sp. H23M54]
VRTTVDLPPSVHQRARRLAAEQGRSLSAVVAELTTRGLAQLDAPAVLTLDELTGLPVLSIGRPISTDEVAEILDDE

Nucleotide

• Length: 231 bp

>AT128763 NZ_CP041616:661618-661848 [Ornithinimicrobium sp. H23M54]
GTGCGAACGACAGTCGACCTCCCCCCGAGCGTGCATCAACGTGCCCGGCGGCTGGCGGCGGAGCAGGGTAGGTCGCTGTC
TGCGGTGGTGGCTGAACTGACGACTCGCGGGCTCGCGCAACTCGATGCTCCTGCTGTTCTGACCCTCGATGAGCTGACCG
GACTGCCCGTGCTCAGCATCGGTCGCCCGATCAGCACGGACGAGGTCGCCGAGATCCTCGACGACGAATGA