Detailed information of TA system TA128761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 166253..166775
• Replicon: chromosome
• Accession: NZ_CP041616
• Organism: Ornithinimicrobium sp. H23M54

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FNH13_RS00815
• Protein ID: WP_143781702.1
• Coordinates: 166497..166775 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FNH13_RS00810
• Protein ID: WP_143784874.1
• Coordinates: 166253..166516 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNH13_RS00770	161335..161808	-	474	WP_143784873.1	hypothetical protein	-
FNH13_RS00775	161823..163334	-	1512	WP_143781695.1	amidase	-
FNH13_RS00780	163392..163694	-	303	WP_143781696.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FNH13_RS00785	163736..164680	-	945	WP_143781697.1	cold shock domain-containing protein	-
FNH13_RS00790	164756..165109	+	354	WP_143781698.1	alcohol dehydrogenase	-
FNH13_RS00795	165095..165244	-	150	WP_143781699.1	toxin-antitoxin system HicB family antitoxin	-
FNH13_RS00800	165557..165838	+	282	WP_143781700.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FNH13_RS00805	165853..166149	+	297	WP_143781701.1	HigA family addiction module antidote protein	-
FNH13_RS00810	166253..166516	+	264	WP_143784874.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FNH13_RS00815	166497..166775	+	279	WP_143781702.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FNH13_RS00820	166957..168378	-	1422	WP_143781703.1	serine hydrolase	-
FNH13_RS00830	168758..169507	-	750	WP_165699959.1	class I SAM-dependent methyltransferase	-
FNH13_RS00835	169980..170348	-	369	WP_114905512.1	hypothetical protein	-
FNH13_RS00840	170895..171455	-	561	WP_202878839.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (13-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10365.82 Da
• Isoelectric Point: 10.2313

>T128761 WP_143781702.1 NZ_CP041616:166497-166775 [Ornithinimicrobium sp. H23M54]
MQRYAPDGGAVQVAWTPTAKRALQRPPEKVATAAIEVIYGPLASNPQRVGKAPRFDLEELHSARRGDDRILYRINERVTI
IAIEHRADVYRS

Nucleotide

• Length: 279 bp

>T128761 NZ_CP041616:166497-166775 [Ornithinimicrobium sp. H23M54]
TTGCAACGCTACGCGCCTGATGGTGGAGCAGTACAGGTCGCGTGGACGCCGACGGCCAAGCGCGCCCTGCAGCGACCGCC
CGAAAAGGTGGCTACGGCGGCTATCGAGGTCATCTACGGTCCACTCGCGAGCAACCCCCAGCGCGTCGGCAAAGCCCCGC
GTTTCGACCTCGAAGAGCTGCACAGCGCTCGACGTGGTGACGACCGGATCCTCTACCGGATCAACGAGCGCGTGACCATC
ATCGCAATCGAACATCGTGCGGACGTCTATCGATCATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9597.96 Da
• Isoelectric Point: 5.7363

>AT128761 WP_143784874.1 NZ_CP041616:166253-166516 [Ornithinimicrobium sp. H23M54]
MALRDVKNRLSEVVDQVEREHDRVVITRHGKPAAVVIRADDLESLAETLKVVSRPKLNTQVRDSLAELAAGEAEVLSKDE
VVATLRA

Nucleotide

• Length: 264 bp

>AT128761 NZ_CP041616:166253-166516 [Ornithinimicrobium sp. H23M54]
ATGGCCCTGCGAGATGTGAAGAATCGGCTGTCCGAGGTGGTGGACCAGGTCGAGCGGGAGCATGACCGGGTCGTGATCAC
TCGTCACGGCAAGCCGGCGGCGGTGGTCATCCGCGCCGACGACCTCGAGTCGTTGGCGGAGACGCTGAAGGTCGTGAGCC
GACCCAAACTCAACACACAGGTCCGAGACAGCCTTGCCGAGCTCGCGGCCGGCGAGGCCGAGGTCCTCAGCAAAGACGAA
GTCGTTGCAACGCTACGCGCCTGA