Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 84184..84892 Replicon chromosome
Accession NZ_CP041616
Organism Ornithinimicrobium sp. H23M54

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNH13_RS00375 Protein ID WP_165699949.1
Coordinates 84184..84624 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FNH13_RS00380 Protein ID WP_143781623.1
Coordinates 84626..84892 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNH13_RS00340 79300..80223 - 924 WP_143781616.1 alanine racemase -
FNH13_RS00345 80306..81043 + 738 WP_143781617.1 class I SAM-dependent methyltransferase -
FNH13_RS00350 81132..82157 + 1026 WP_143781618.1 ATP-dependent 6-phosphofructokinase -
FNH13_RS00355 82154..82939 + 786 WP_143781619.1 CPBP family intramembrane metalloprotease -
FNH13_RS00360 83035..83235 + 201 WP_143781620.1 hypothetical protein -
FNH13_RS00365 83232..83630 + 399 WP_202878836.1 AraC family transcriptional regulator -
FNH13_RS00370 83707..84150 + 444 WP_143781621.1 VOC family protein -
FNH13_RS00375 84184..84624 - 441 WP_165699949.1 PIN domain-containing protein Toxin
FNH13_RS00380 84626..84892 - 267 WP_143781623.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FNH13_RS00385 84907..86160 - 1254 WP_202878837.1 MFS transporter -
FNH13_RS00390 86163..86639 - 477 WP_143784868.1 MarR family winged helix-turn-helix transcriptional regulator -
FNH13_RS00395 86841..88157 + 1317 WP_143781625.1 threonine ammonia-lyase IlvA -
FNH13_RS00400 88180..88875 - 696 WP_143781626.1 M50 family metallopeptidase -
FNH13_RS00405 88987..89493 - 507 WP_143781627.1 nucleoside deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15844.10 Da        Isoelectric Point: 6.7547

>T128759 WP_165699949.1 NZ_CP041616:c84624-84184 [Ornithinimicrobium sp. H23M54]
VLFLDVNVCLDAFRPTSSEDAGRVHSWLASRLTGDEQLGLSEFVLSAMVRIATHPKIYAEPAPVGAALDFADALLAAPAT
TVVRPGGHHWRLFSDLARTYDLRGNHIPDAYLAALAMEHAGTLVTRDRRIGRFSGLRTLDPLIAQA

Download         Length: 441 bp

>T128759 NZ_CP041616:c84624-84184 [Ornithinimicrobium sp. H23M54]
GTGCTCTTCCTCGACGTCAACGTCTGCCTCGATGCCTTCCGTCCCACCTCATCGGAGGATGCCGGCAGAGTCCACTCGTG
GCTGGCGTCACGGTTGACCGGCGATGAGCAGCTCGGCCTCAGCGAGTTCGTGCTGTCGGCGATGGTGCGCATCGCCACGC
ACCCGAAGATCTATGCCGAGCCCGCCCCGGTGGGTGCGGCACTCGACTTTGCGGACGCGTTGCTGGCAGCACCCGCGACC
ACGGTGGTGCGGCCGGGCGGGCACCACTGGCGTCTGTTCAGCGACTTGGCCAGGACCTACGACCTACGGGGCAACCACAT
CCCCGACGCCTATCTCGCGGCCCTGGCCATGGAGCACGCAGGCACCCTCGTCACCCGGGATCGTCGCATCGGGCGATTCT
CCGGGCTGCGCACGCTTGATCCGTTGATCGCGCAGGCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9503.67 Da        Isoelectric Point: 4.6509

>AT128759 WP_143781623.1 NZ_CP041616:c84892-84626 [Ornithinimicrobium sp. H23M54]
MRTTVTIDEHLLAEAKILAARGHRTIGSVLEDALRLLLAEHSRRAEVAGDFSLPTFEPDDPGVRPGIDLLDREALAEALG
DNTTASRS

Download         Length: 267 bp

>AT128759 NZ_CP041616:c84892-84626 [Ornithinimicrobium sp. H23M54]
ATGCGCACGACAGTGACGATCGACGAGCACCTCCTCGCTGAGGCCAAGATCCTGGCGGCGCGGGGGCACCGGACCATTGG
CTCGGTGCTGGAGGACGCGCTGCGCCTGCTTCTTGCGGAACACTCGCGGCGGGCCGAGGTGGCGGGGGACTTCAGCCTGC
CGACCTTCGAGCCGGACGATCCTGGTGTTCGCCCCGGCATCGACCTGCTGGACCGCGAGGCACTGGCGGAGGCGCTCGGA
GACAACACCACTGCCTCACGGAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References