Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3358804..3359457 Replicon chromosome
Accession NZ_CP041587
Organism Acinetobacter baumannii strain J9

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag FK728_RS15855 Protein ID WP_000607071.1
Coordinates 3358804..3359193 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag FK728_RS15860 Protein ID WP_001288210.1
Coordinates 3359200..3359457 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FK728_RS15840 3353922..3356117 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
FK728_RS15845 3356305..3356871 - 567 WP_000651536.1 rhombosortase -
FK728_RS15850 3356949..3358034 - 1086 WP_000049106.1 hypothetical protein -
FK728_RS15855 3358804..3359193 - 390 WP_000607071.1 membrane protein Toxin
FK728_RS15860 3359200..3359457 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
FK728_RS15865 3359645..3360817 + 1173 WP_111916272.1 acyl-CoA dehydrogenase family protein -
FK728_RS15870 3360866..3362356 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
FK728_RS15875 3362538..3362915 - 378 WP_001216380.1 50S ribosomal protein L17 -
FK728_RS15880 3362934..3363941 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T128754 WP_000607071.1 NZ_CP041587:c3359193-3358804 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T128754 NZ_CP041587:c3359193-3358804 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT128754 WP_001288210.1 NZ_CP041587:c3359457-3359200 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT128754 NZ_CP041587:c3359457-3359200 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References