Detailed information of TA system TA128753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1163361..1164012
• Replicon: chromosome
• Accession: NZ_CP041587
• Organism: Acinetobacter baumannii strain J9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FK728_RS05600
• Protein ID: WP_000838150.1
• Coordinates: 1163361..1163543 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FK728_RS05605
• Protein ID: WP_000966685.1
• Coordinates: 1163608..1164012 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FK728_RS05560	1159323..1159985	+	663	WP_001284678.1	hypothetical protein	-
FK728_RS05565	1160053..1160466	+	414	WP_000626004.1	hypothetical protein	-
FK728_RS05570	1160432..1160800	+	369	WP_001983390.1	hypothetical protein	-
FK728_RS05575	1160802..1161200	+	399	WP_001251842.1	hypothetical protein	-
FK728_RS05580	1161202..1161414	+	213	WP_001983388.1	hypothetical protein	-
FK728_RS05585	1161522..1162451	+	930	WP_000094301.1	hypothetical protein	-
FK728_RS05590	1162496..1163029	+	534	WP_001185623.1	hypothetical protein	-
FK728_RS05600	1163361..1163543	+	183	WP_000838150.1	type II toxin-antitoxin system HicA family toxin	Toxin
FK728_RS05605	1163608..1164012	+	405	WP_000966685.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FK728_RS05610	1164111..1164287	+	177	WP_001983384.1	hypothetical protein	-
FK728_RS05615	1164296..1164619	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
FK728_RS05620	1164653..1165186	+	534	WP_000719143.1	hypothetical protein	-
FK728_RS05625	1165198..1165599	+	402	WP_000758223.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1135093..1191394	56301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6622.83 Da
• Isoelectric Point: 10.7364

>T128753 WP_000838150.1 NZ_CP041587:1163361-1163543 [Acinetobacter baumannii]
VKSLDLVKMIEADGWYLVRVKGSHHHFKHPTKGGLVTIPHPKKELPSGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T128753 NZ_CP041587:1163361-1163543 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAGTCAAAATGATTGAAGCAGACGGTTGGTACTTAGTTAGGGTTAAAGGAAGTCATCATCACTT
CAAACATCCAACTAAAGGGGGCTTAGTTACTATCCCTCACCCAAAAAAGGAATTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14618.61 Da
• Isoelectric Point: 4.4169

>AT128753 WP_000966685.1 NZ_CP041587:1163608-1164012 [Acinetobacter baumannii]
MLYPIAIERGNDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT128753 NZ_CP041587:1163608-1164012 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATAGAAAGAGGTAACGACACCGAGGCATTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG