Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1008858..1009513 Replicon chromosome
Accession NZ_CP041585
Organism Neisseria gonorrhoeae strain NJ1711654

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag FNL98_RS06010 Protein ID WP_003691083.1
Coordinates 1009094..1009513 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag FNL98_RS06005 Protein ID WP_003688410.1
Coordinates 1008858..1009094 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNL98_RS05965 1003992..1004279 + 288 WP_025455945.1 hypothetical protein -
FNL98_RS05970 1004351..1005517 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
FNL98_RS05975 1005528..1006418 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
FNL98_RS05985 1006801..1007187 - 387 Protein_1011 IS110 family transposase -
FNL98_RS05990 1007399..1007827 + 429 WP_010360042.1 helix-turn-helix domain-containing protein -
FNL98_RS05995 1007832..1008410 + 579 WP_003688041.1 IS3 family transposase -
FNL98_RS06000 1008455..1008652 + 198 WP_033910354.1 IS3 family transposase -
FNL98_RS06005 1008858..1009094 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
FNL98_RS06010 1009094..1009513 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
FNL98_RS06015 1009662..1011116 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
FNL98_RS06020 1011113..1011814 - 702 WP_003688414.1 lactate utilization protein C -
FNL98_RS06025 1011811..1012590 - 780 WP_003688416.1 (Fe-S)-binding protein -
FNL98_RS06030 1012738..1014279 + 1542 WP_003701286.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T128751 WP_003691083.1 NZ_CP041585:1009094-1009513 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T128751 NZ_CP041585:1009094-1009513 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT128751 WP_003688410.1 NZ_CP041585:1008858-1009094 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT128751 NZ_CP041585:1008858-1009094 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References