Detailed information of TA system TA128735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 867969..868788
• Replicon: chromosome
• Accession: NZ_CP041515
• Organism: Klebsiella michiganensis strain KNU07

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: FNA74_RS05310
• Protein ID: WP_004110819.1
• Coordinates: 867969..868226 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: FNA74_RS05315
• Protein ID: WP_143444293.1
• Coordinates: 868237..868788 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNA74_RS05295	863645..864421	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
FNA74_RS05300	864560..866035	-	1476	WP_014228053.1	fructuronate reductase	-
FNA74_RS05305	866109..867293	-	1185	WP_014228054.1	mannonate dehydratase	-
FNA74_RS05310	867969..868226	+	258	WP_004110819.1	YjhX family toxin	Toxin
FNA74_RS05315	868237..868788	+	552	WP_143444293.1	N-acetyltransferase	Antitoxin
FNA74_RS05320	868806..870434	+	1629	WP_064358622.1	SAM-dependent methyltransferase	-
FNA74_RS05325	870559..871899	-	1341	WP_032748099.1	carbohydrate porin	-
FNA74_RS05330	872021..873418	-	1398	WP_014228060.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (23-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T128735 WP_004110819.1 NZ_CP041515:867969-868226 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T128735 NZ_CP041515:867969-868226 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19986.82 Da
• Isoelectric Point: 6.2120

>AT128735 WP_143444293.1 NZ_CP041515:868237-868788 [Klebsiella michiganensis]
MTNHSFTFHVTSEGDTDDILNVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRLGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWCE

Nucleotide

• Length: 552 bp

>AT128735 NZ_CP041515:868237-868788 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCACCTCTGAAGGCGATACCGATGACATTCTCAACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCTCGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGTGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2