Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3859820..3860651 Replicon chromosome
Accession NZ_CP041513
Organism Shigella boydii strain KCCM 41690

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FNA65_RS20945 Protein ID WP_000854814.1
Coordinates 3860277..3860651 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FNA65_RS20940 Protein ID WP_001285585.1
Coordinates 3859820..3860188 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA65_RS20910 3855967..3856266 - 300 Protein_3820 IS1 family transposase -
FNA65_RS20920 3857579..3858409 + 831 WP_039059216.1 DUF945 domain-containing protein -
FNA65_RS20925 3858491..3858970 + 480 WP_000860059.1 antirestriction protein -
FNA65_RS20930 3858986..3859462 + 477 WP_012421636.1 RadC family protein -
FNA65_RS20935 3859525..3859746 + 222 WP_000692323.1 DUF987 domain-containing protein -
FNA65_RS20940 3859820..3860188 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FNA65_RS20945 3860277..3860651 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FNA65_RS20950 3860648..3860842 + 195 WP_000988600.1 hypothetical protein -
FNA65_RS20955 3860855..3860968 + 114 WP_001161660.1 DUF957 domain-containing protein -
FNA65_RS20960 3861357..3862484 + 1128 WP_001063816.1 IS110-like element ISSso6 family transposase -
FNA65_RS20965 3862751..3862990 - 240 Protein_3831 nickel/cobalt efflux protein RcnA -
FNA65_RS20970 3863111..3863383 + 273 WP_000019944.1 Ni(II)/Co(II)-binding transcriptional repressor RcnR -
FNA65_RS20975 3863606..3864394 + 789 WP_001195636.1 hydroxyethylthiazole kinase -
FNA65_RS20980 3864391..3865191 + 801 WP_000822274.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3844887..3862484 17597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T128724 WP_000854814.1 NZ_CP041513:3860277-3860651 [Shigella boydii]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T128724 NZ_CP041513:3860277-3860651 [Shigella boydii]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT128724 WP_001285585.1 NZ_CP041513:3859820-3860188 [Shigella boydii]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT128724 NZ_CP041513:3859820-3860188 [Shigella boydii]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References