Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1304147..1304801 Replicon chromosome
Accession NZ_CP041513
Organism Shigella boydii strain KCCM 41690

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag FNA65_RS07505 Protein ID WP_000244777.1
Coordinates 1304147..1304554 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2S8DWY8
Locus tag FNA65_RS07510 Protein ID WP_039059554.1
Coordinates 1304535..1304801 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA65_RS07485 1300104..1301837 - 1734 WP_000813182.1 single-stranded-DNA-specific exonuclease RecJ -
FNA65_RS07490 1301843..1302553 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FNA65_RS07495 1302578..1303474 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FNA65_RS07500 1303586..1304107 + 522 WP_001055874.1 flavodoxin FldB -
FNA65_RS07505 1304147..1304554 - 408 WP_000244777.1 toxin CptA Toxin
FNA65_RS07510 1304535..1304801 - 267 WP_039059554.1 FAD assembly factor SdhE Antitoxin
FNA65_RS07515 1305044..1306024 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
FNA65_RS07520 1306220..1306879 - 660 WP_000250274.1 hemolysin III family protein -
FNA65_RS07525 1307043..1307354 - 312 WP_001182969.1 N(4)-acetylcytidine aminohydrolase -
FNA65_RS07530 1307399..1308832 + 1434 WP_024258645.1 6-phospho-beta-glucosidase BglA -
FNA65_RS07535 1308889..1309632 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T128720 WP_000244777.1 NZ_CP041513:c1304554-1304147 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T128720 NZ_CP041513:c1304554-1304147 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10577.15 Da        Isoelectric Point: 4.8727

>AT128720 WP_039059554.1 NZ_CP041513:c1304801-1304535 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
WERGPVAI

Download         Length: 267 bp

>AT128720 NZ_CP041513:c1304801-1304535 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
TGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8DWY8

References